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Biomedical Science and Research Journals | Application of Monte Carlo Method for Simulation of Covid-19 Epidemic Behavior

  Application of Monte Carlo Method for Simulation of Covid-19 Epidemic Behavior Abstract There is no any valid simulation for COVID-19 spreading behavior especially its herd immunity. Herd Immunity is going to play very important role in COVID-19 issue because of lack of treatment drugs and vaccination. Herd immunity thresholds constitute convenient targets for vaccination coverage too. Therefore, present Monte Carlo simulation is very important and applicable for both herd immunity and vaccination scenarios. Calculation of important factors, especially basic reproductive ratio Ro, may be used in both vaccine scenario and herd immunity. It may be also used for prediction of COVID-19 behavior in any city or society using our Monte Carlo simulation. Mini Review At the end of 2019, a novel coronavirus (COVID-19), was identified as the cause of a cluster of pneumonia cases in Wuhan, China. It rapidly spread, resulting in an epidemic throughout China, with sporadic cases reported globally
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Biomedical Science and Research Journals | Fatal Multidrug-Resistant Klebsiella pneumonia Sepsis Episodes in Eight Liver Transplant Recipients

  Fatal Multidrug-Resistant Klebsiella pneumonia Sepsis Episodes in Eight Liver Transplant Recipients Abstract Objective:  Solid organ transplant recipients are especially at risk for infection by multidrug-resistant bacteria. We aimed to state that high mortality in eight patients undergone liver transplantation and having recurrent multidrug-resistant  Klebsiella pneumonia  sepsis within the first year after liver transplantation despite given different antibiotic therapies according to the antimicrobial susceptibility tests. Cases:  Our case series include eight adult recipients who undergone liver transplantation in our institute in 2018. We retrospectively reviewed all demographic data by using patient record system. Antimicrobial treatment records of patients were obtained from the hospital pharmacy medicine exits and the nurse observation records. Mean age of the eight cases was 47.25±32. After liver transplantation, intraabdominal abscess and infected bilioma due to biliary lea
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Biomedical Science and Research Journals | The Structures and Functions of Vaccinia Virus E3L and Protein Kinase R

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  The Structures and Functions of Vaccinia Virus E3L and Protein Kinase R Abstract The Vaccinia Virus (VV) E3L of the poxvirus family encodes double-stranded RNA-binding, which promote viral growth and pathogenesis by inhibiting innate immunity. E3L gene of vaccinia virus also acts as a multifunctional viral immune factor that blocks host defense factors from participating in the induction and action of Interferon (IFN). In other words, the main function of E3L is to block the activations of Interferon Regulatory Factor 3 (IRF3), RNase L, and Protein Kinase R (PKR) simultaneously. These inhibitions may be achieved by combining Double-Stranded RNA (dsRNA) isolation with direct inhibitions of protein-protein interactions. Meanwhile, dsRNA-dependent serine/threonine protein kinase induced by IFN plays a key role in innate immune response to viral infection and key regulatory roles during signal transduction, cell proliferation and differentiation, and apoptosis. Furthermore, activation of
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Biomedical Science and Research Journals | Pathophysiological Aspects of the Use of Hypobaric Hypoxic Training in the Treatment of Anemia in Chronic Glomerulonephritis

  Pathophysiological Aspects of the Use of Hypobaric Hypoxic Training in the Treatment of Anemia in Chronic Glomerulonephritis Summary The course of chronic glomerulonephritis (CGN) is often accompanied by the development of anemia, which contributes to the progression of chronic kidney disease (CKD) and, in severe cases, leads to death. Therefore, correction of renal anemia at the earliest stages of CKD is important, allowing to reduce the rate of progression of renal dysfunction and delaying the onset of renal replacement therapy. Currently, erythropoietin is widely used in the treatment of renal anemia, which, however, is not always available to most patients due to its high cost. In this regard, the possibility of using it for this purpose, along with erythropoietin, and hypobaric hypoxic training, anti-anemic efficacy of which is proved by numerous studies, is of interest. The purpose of the study is to evaluate the effectiveness of correction of anemia with erythropoietin (EPO ß)
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Biomedical Science and Research Journals | Road Rage in the Doctor’s Office

  Road Rage in the Doctor’s Office Editorial A man appears in my office. Distinguished looking, a CEO, in his early 70’s. He is here because he has minor, intermittent knee pain. His exam and XR’s are consistent with early osteoarthritis. I suggest that he take an anti-inflammatory medication such as Motrin when needed. He tells me that Motrin works well and he has no problem tolerating it, but that he doesn’t intend to take pills for the rest of his life. He says he wants to have his knee fixed. When I realize that he is talking about a total joint replacement, I suggest that this is perhaps premature, considering how well he is functioning, and that even if the surgery goes smoothly, a joint replacement is never as good as one’s own knee. I repeat that surgery is perhaps not the appropriate treatment for the minor symptoms that he is having. He repeats that he wants his knee fixed. He insists on a second opinion. What is wrong with this picture? Or this one An engineer in his forties
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