BiomedGrid

  Religion and Public Health Amidst the Covid-19 Pandemic Opinion The progression of the Coronavirus disease 2019 (COVID-19) towards the pandemic [1], witnessed a dialogue on religion; on one hand to strengthen the efforts of public health agencies by quoting tenets of religion that parallel and promote measures to curb the spread of the infection, and on the other hand, defying the protocols set by governing bodies by engaging in public gatherings in places of worship, creating foci for propagating the infection [2]. This discourse grows in the domains of journalism and social media, with direct implications on the health behaviour of individuals, in agreement or disagreement with the arguments. However, there seems to be a harmful silence in academic discourse on the study of this relationship, towards supplementing the efforts of governments and frontline workers, and protecting them from risk taking health behaviour, influenced by religion. In the context of public health, reli...

  The Potential Detrimental Effects on Multiple Organ Systems in COVID-19 Patients Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes COVID-19, which spreads between people, mainly when an infected person stays in close contact with another one. The infection starts off with mild flu-like symptoms to severe in the several aspects. In the most cases, COVID-19 patients usually develop mild to moderate illness and recover at home stay with nominal medications. The usual signs of COVID-19 are fever, dry cough, loss of taste, tiredness etc., in very rare cases symptoms are difficulty in breathing, muscle pain, chest pain, loss of speech or movement etc. The deceased people from COVID-19 reveal the expected features of severe pneumonia or acute respiratory distress syndrome (ARDS). The virus seems to directly cause inflammation in the small capillaries or blood vessels leading to blood clots and damage heart, liver, brain and kidneys. In some people, it can affe...

  Difficulties of CIDP Diagnosis Introduction Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune neuropathy characterized by weakness and/or sensory symptoms developing over more than 8 weeks and hipo or areflexia. It is worth emphasizing that CIDP is the most common treatable neuropathy in the world [1]. It is important to include it in the differential diagnosis, as some studies suggest that CIDP is misdiagnosed in up to 47% of patients [2]. The reason of this phenomen is multifactorial, from diverse clinical presentation, especially misleading in atypical variants, through electrodiagnostic pitfalls to objective estimation of the treatment response. In this article we discuss the difficulties of diagnosis CIDP with particular emphasis on atypical variants. CIDP Epidemiology and Diagnostic Criteria The prevalence of CIDP is 0.46 - 1.83 persons per 100.000 [3,4]. The disease occurs in all age groups, but the incidence increases with age, peaking in middle-ag...

  HSPA12B Expression as an Epigenetic Signature Following Ischemic Stroke: Heat Shock Protein Mini Review Abstract Stroke is a cardiovascular condition that caused by a clot or obstruction that prevents blood from flowing to the brain. Neural cells within the occluded area undergo cell death within minutes, and the results are often permanent, making stroke one of the leading causes of serious longterm disability. Stroke is a complex disorder that requires innovative solutions to attenuate the effects of stroke and improve clinical outcomes. Traditionally, stroke treated by relieving vascular occlusions and restoring blood flow to the infarcted tissue (necrotic tissue; core infarct) and the surrounding tissue at risk (penumbra). This technique known as thrombolysis, utilizing both chemical and mechanical modes. Chemical thrombolysis utilizes a catheter that administers medication to the clot site, which includes a multitude of treatments that include intravenous (IV) thrombolysis w...

  Gastric Metastasis from Ovarian Carcinoma Revealed by Digestive Hemorrhage: Case Report Abstract Background:  Gastric metastases due to ovarian carcinoma are extremely rare and the patients' prognosis is poor. We report a case of gastric ovarian cancer metastases revealed by gastrosplenic perforation. The secondary gastric tumor appeared seven years after the diagnosis of primary cancer. Case presentation:  The patient is a 71-year-old woman with a serous ovarian cancer hospitalized for asthenia with digestive hemorrhage. At esophagogastroduodenoscopy, a protruding mass was noted at the level of the gastric antrum. She underwent a hemostasis of an endoscopic hemostasis by argon plasma; with effective hemostasis. The final pathology revealed gastric metastases of serous ovarian adenocarcinoma. Weekly gemcitabine chemotherapy was adopted, but the disease progressed rapidly. The patient died 4 months later. Conclusion:  We have reported a case of gastric metastasis of...

  Utilizing Pharmacogenomics to Reduce Adverse Drug Events Abstract Objective : The objective of this publication is to describe how pharmacogenomic testing can help reduce the incidence of ADEs. Summary:  Pharmacogenomic testing identifies genetic variants that help clinicians determine an individual’s expected response to medications. Results from pharmacogenomic testing may provide valuable information on the expected response to a drug while on the other hand, results may also help explain adverse drug events (ADEs), identify patients who may require closer monitoring to avoid ADEs, and avoid specific drugs that are expected to cause ADEs in certain individuals. Many ADEs are believed to have a genetic component. Drugs administered at normal doses may interact with a gene that has a genetic variant affecting the drug’s response. Pharmacogenomic testing can identify genetic variants that encode specific CYP enzymes (e.g., CYP2C9, CYP2C19, CYP2D6, and CYP3As). It is estimate...