BiomedGrid

  The Activity of 2,3-Dimethylquinoxaline against Madurella mycetomatis Abstract Objective:   Madurella mycetomatis  is the most prevalent causative species of the eumycetoma, a chronic progressive neglected tropical disabling infectious disease of the subcutaneous tissue. It carries a significant social and economic burden to the endemic areas. Unfortunately, the available treatment is challenging, requires prolonged therapy, resulting in low cure rates and a high incidence of recurrence. Screening new compounds for antifungal activity against  Madurella mycetomatis  is needed. Design:  In vitro: the susceptibility of a  Madurella mycetomatis  isolate toward the 2,3-dimethylquinoxaline was determined. In vivo: the efficacy of 2,3-dimethylquinoxaline 1% topical gel against the same strain was evaluated in the BALB/c mouse eumycetoma model (n=6; 6-8 weeks old). Results:  2,3-Dimethylquinoxaline inhibited the growth of  Madurella mycetomat...

  Difficulties of CIDP Diagnosis Introduction Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune neuropathy characterized by weakness and/or sensory symptoms developing over more than 8 weeks and hipo or areflexia. It is worth emphasizing that CIDP is the most common treatable neuropathy in the world [1]. It is important to include it in the differential diagnosis, as some studies suggest that CIDP is misdiagnosed in up to 47% of patients [2]. The reason of this phenomen is multifactorial, from diverse clinical presentation, especially misleading in atypical variants, through electrodiagnostic pitfalls to objective estimation of the treatment response. In this article we discuss the difficulties of diagnosis CIDP with particular emphasis on atypical variants. CIDP Epidemiology and Diagnostic Criteria The prevalence of CIDP is 0.46 - 1.83 persons per 100.000 [3,4]. The disease occurs in all age groups, but the incidence increases with age, peaking in middle-ag...

  On Cloud Analytical Database Management Systems Suitable for Data Intensive Biomedical Related Research Introduction Per to Worldometer [1], as of mid-December 2020, there are more than 77 million Covid-19 cases worldwide with more than 1.7 million deaths worldwide. Unfortunately, with the second wave hitting many countries, positive cases are increasing rapidly at astonishing rates. Along with that, a large amount of data, both directly and indirectly related to Covid-19, is generated ready to be minded supporting decision makers, scientists, corporations, drug makers, etc. [2]. Two immediate questions naturally would be (2) where we should store the data and (2) what Database Management Systems (DBMS) we should use to analyze the data? To benefit from easy access and to accommodate sharp growth in data volume, it is hard to dispute that the data should be stored in the cloud. In this position paper, we will present our recommendations based on our more than five years of using ...

  COVID 19 Emergency Multimedia Rehabilitation Assistance: Case Report Introduction The data concerning the Coronavirus 2019-nCov identify minors with complex chronic pathologies a population at increased risk and therefore neuromotor disability represents a target in need of particular attention. And in fact, ministerial and regional directives have recommended to family members and caregivers of fragile children to engage in behavior aimed at reducing the risk of contagion, including, among other things, the reduction of access to health and rehabilitation services for elective services. not urgent or postponed. Although children are less affected and have a lower risk of developing complications related to viral infection, there is actually no evidence that they, more difficult to limit in contacts, cannot act as vectors, in particular asymptomatic; and also, an increase in the frequency of children with Kawasaki disease has been reported, especially in the areas most affected b...

  What Uses of Connected Mobile Microsensors of Air Pollution in the General and Vulnerable Populations? Abstract This review article summarizes the potential uses of mobile microsensors by the public and some vulnerable populations. Firstly, use of such sensors could help promote individual behaviors aimed at limiting exposures and the generation of air pollutants. However, access to the best information, if taken alone, does not necessarily translate into a change in individual behavior. Knowledge can promote changes in behavior when there are measures available that can be implemented and if the benefits of the actions can be verified in the short run and if they are combined with coaching by scientific or medical experts. Secondly, the use of mobile sensors could promote collective behavior and influence public policies that promote air quality. Nowadays, information intended for the public is only provided through media outlets during periods of elevated air pollution and cons...