BiomedGrid

  Delivering Health and Care in the Digital Era depends on Forging New Partnerships Opinion “Blue sky thinking” is a perfect description for digital health: the potential is clear, the space vast and wide open. However, still countless digital health initiatives are underway around the world without overarching vision or coordinating mechanisms. This piecemeal approach makes it difficult to scale effective solutions and realize the full potential of digital in health systems. That would require new partnerships to be forged and digital technology to become integral part of every health system [1]. The Broadband Commission led by ITU and UNESCO advocates for the transformational impact of broadband technologies for development [2]. Its working group on digital health has synthesized best practices for countries to realize the potential of digital technology in health and care. The group’s first two reports laid the groundwork by explaining the need for government leadership and inte...

  COVID-19 Pandemic and Medical Education in a Developing Country Short Communication In March 2020, the World Health Organization considered coronavirus disease-2019 (COVID-19) as a worldwide pandemic [1]. This leads to serious effects on medical education in medical schools. Medical students are potentially susceptible to COVID-19 owing to their contact with in-patients during the clinical teaching classes and their common rotation between the hospital depart ments [2]. Closure of medical schools and continuing the educational process from home for both staff and students became urgent to ensure social distancing. As the COVID-19 problem evolved in Egypt, education in the whole universities was suspended for several weeks. The classes for all six years of the undergraduate medical teaching were stopped. This had a detrimental effect on medical students due to less exposure for clinical teaching classes and patient examination. Clinical teaching and exams using live patients are a...

  Sympathetic Nerve Control of Blood Pressure Response during Exercise in Peripheral Artery Disease and Current Application of Experimental Disease Models Abstract In patients with peripheral artery disease (PAD), the blood supply directed to the lower limbs is reduced. This results in severe limb ischemia and thereby intermittent claudicating which is characterized by pain in lower limbs that occurs with walking and is relieved by rest. Of note, PAD can extremely affect the quality of living of patients and increase high risk of coronary and cerebral vascular accidents. However, effective treatments of PAD are still challenging in clinics. A number of reports have demonstrated the beneficial effects of supervised exercise on symptoms of PAD patients. This review will summarize results obtained from recent human and animal studies, which include the abnormalities in sympathetic control of blood pressure response during exercise in PAD, and rationality of animal models used for stud...

  Evaluation of The Pressure Ulcers after Using Barrier Cream in Intensive Care Unit Introduction A pressure ulcer (PU) is specified by National Pressure Ulcer Advisory Panel (NPUAP) as localized cutaneous or subcutaneous tissue damage that occurs on bone protrusions whether alone or in combination with shear stress [1]. Clinicians often use a four-grade system as defined by NPUAP for consistency in diagnosing and treatment; Grade 1 non-blanchable erythema with intact skin, Grade 2 partial skin loss of the dermis, Grade 3 full thickness skin loss with exposed dermis and Grade 4 deep tissue loss and injury exposure of bone, tendon and muscle [1]. Pressure ulcers are caused by multiple factors such as immobilization, malnutrition, advanced age, urine and/or faeces contamination, overhydration and friction [2]. In intensive care units (ICUs) because of mechanical ventilation, limited immobilization, widespread use of anesthetic, sedative and muscle relexant drugs and circulatory venti...

  The Porcine Experimental Model for Oocyte Cryopreservation by Vitrification Abstract Pigs have anatomical-physiological similarities with the human in several aspects, mainly in the reproduction function, which is of great interest in this review. However, in oocytes, there are differences between both species, impacting the vitrification success. For example, porcine oocytes have higher intracellular lipid content than women oocytes, affecting cryoprotectant permeability and increasing ice crystal formation. Despite these differences, the porcine model has been important for the development of assisted reproduction technologies in humans, as well as in the genetic improvement of livestock. Importance of the Porcine Experimental Model Since its domestication 7000-9000 BC, the porcine species have been historically significant as a food source for humans. In the 1950s, it began as a possible experimental model in biomedical research. Some of the most important events are the isola...

  Probiotics as Potential Therapeutics for Colorectal Cancer Abstract Much health benefits by lactic acid bacteria (LAB) have been observed via in-vivo trials. LAB’s health benefits are described such as improving of intestinal microbial balance between probiotics and harmful bacteria, protecting of pathogen infection and modulating of host’s immunity in gut. Colorectal cancer (CRC) located in intestine and its development leads to invade or spread to other parts of the body result in death. Recent many publications about LAB have demonstrated the immense potential as alternative bio-therapeutics. Actually, LAB have been reported to be the safe bio-therapeutic with positive effects against various cancer types including CRC. In this review, we discuss the evidences of beneficial effects of LAB application and its molecular mechanisms. Keywords:  Lactic acid bacteria; Probiotics; Colorectal cancer; Bio-therapeutics; Anti-cancer activity Introduction Colorectal cancer (CRC) deve...