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Biomedical Science and Research Journals | Natural Products for the Therapy of Proteinopathies Underlying the Neurodegenerative Conditions: Protein Misfolding and Fibrillization in Alzheimer’s Disease and Parkinson’s Disease

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Natural Products for the Therapy of Proteinopathies Underlying the Neurodegenerative Conditions: Protein Misfolding and Fibrillization in Alzheimer’s Disease and Parkinson’s Disease Introduction Significant progress has been made in our understanding of dysregulated proteostasis and protein misfolding which underlie the pathogenesis of such neurodegenerative diseases as Alzheimer’s disease (AD) and Parkinson’s disease (PD). In the 1990s the kinetics of β-amyloid (Aβ) fibrillization was well characterized [1,2]. Epidemiology had shown that mutations in amyloid precursor protein (APP) or the beta- and gamma-secretases which elevate the level of Aβ in the brain, as well as mutations which increase the propensity for Aβ to polymerize, are strongly associated with the development of Alzheimer’s disease. Oligomers of Aβ are more neurotoxic than the monomers [3-5]. These observations suggested that molecules which would interfere with polymerization and fibrillization might slow the progres…

Biomedical Science and Research Journals | Quality Criteria of a Research Output

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Quality Criteria of a Research Output Introduction An autonomous scholar, whether engaged in teaching, research, or professional service, writes with a clear demonstration of satisfying four criteria: originality, rigour, significance, and coherence. The first three are measures of relative quality while the last demands that the work has a unifying theme. In the subsequent subsections we discuss what each criterion could take into account. Originality Originality means different things in different disciplines. Nonetheless it can mean applying existing stances, methodologies or theories to new data; finding new ways of analysing/theorising existing data; proposing new methods/theories for old problems; reinterpreting existing data or theories and revising old views. It can also mean new knowledge or new theories or new connections with previously unrelated materials [1]. Argues that the traditional PhD “privileges the creation of new knowledge over the application, extension, interp…

Biomedical Science and Research Journals | The Genetic Revolution: The Challenges of Genetic Sequencing in Substance-Use Disorders

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The Genetic Revolution: The Challenges of Genetic Sequencing in Substance-Use Disorders Introduction Substance Use Disorders present a global public-health issue and are responsible for approximately 12.4% of deaths worldwide as well as injury or illness in over 40 million individuals every year [1]. Substance Use Disorders are associated with loss of productivity, higher levels of domestic violence, and increased propensity for criminal behavior and incarceration [2]. Due to the high numbers of people affected by this disorder and the large burden it places on society as a whole, developing effective treatment protocols to combat substance Use Disorders is necessary. The brain-disease model can reduce the stigma around addiction as it suggests that the likelihood of substance abuse is influenced by factors such as genetics and neural pathways rather than any moral shortcomings or poor decision-making skills [2]. Next-generation sequencing (NGS) and Genome-Wide Association Studies (G…

Biomedical Science and Research Journals | A Review: Targeted Cancer Therapy as a Fight Against Brain Tumor

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A Review: Targeted Cancer Therapy as a Fight Against Brain Tumor Abstract The brain tumor is the second most deadly disease for causing death among cancer patients. It can be treated by conventional treatment techniques i.e. chemotherapy, neurosurgery, and radiotherapy but with some improvement, it mostly results in the increase of medical problems by non-specific targeting of normal cells in addition to the cancerous cells. Different CNS diseases include cerebrovascular disease, Parkinson’s disease, epilepsy, Alzheimer disease, and other neurogenerative disorders. Despite advance ongoing research, a number of patients are dying every year by these diseases. Different techniques are used including invasive and non- invasive to treat these diseases. Molecular targeting agents are being used which have the advantages of easily crossing multiple barriers i.e. Brain blood barrier (BBB), cerebrospinal fluid (CSF) and brain bloodtumor barrier to reach the malignant site, low tox…

Biomedical Science and Research Journals | Herpetic Encephalitis Associated with Multiple Myeloma: Diagnostic Challenge

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