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Biomedical Science and Research Journals | A Death of Malignant Hyperthermia Performed Autopsy: A Case Report

  A Death of Malignant Hyperthermia Performed Autopsy: A Case Report Abstract Malignant hyperthermia (MH) is a potentially lethal disorder triggered by certain anesthetics. MH is characterized by hypermetabolism, muscle rigidity, hypercapnia, tachycardia, hypoxaemia, respiratory and metabolic acidosis, and hyperthermia. Mutations in the RYR1(account for about half of MH cases), CACNA1S, or STAC3 genes are associated with MH. We report on the case of a 19-year-old girl who is suffering from MH, without history of MH-susceptible and she died suddenly after cardiac arrest for more than 2 hours. The lack of clinical experience and vigilance resulted to the difficulty of early diagnosis. If MH is highly suspected during general anesthesia of potent volatile anaesthetics with or without succinylcholine, a collaborative treatment approach is mandatory, especially treatmented with dantrolene should begin as soon as possible. Autopsy of patients with MH, similar cases are infrequent in the lite
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Biomedical Science and Research Journals | Atrial Autonomic Denervation for The Treatment of Longstanding Symptomatic Sinus Bradycardia: A Case Report

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  Atrial Autonomic Denervation for The Treatment of Longstanding Symptomatic Sinus Bradycardia: A Case Report Abstract A 56-year-old man with symptomatic sinus bradycardia (SB) of 5 years accepted the suggestion of atrial autonomic denervation. Radiofrequency pulses were delivered on atrial ganglionated plexi (GP) with positive vagal reflex according to the standard of heart rate (HR) drop ≥20% after high frequency stimulation (HFS). The endpoint of inexistence of HR decrease at repeating HFS was achieved in 16 sites. After 12 months of follow-up, the patient continued to have normal 24-hour total heart beats and mean heart rate and SB-related symptoms substantially improved. Autonomic denervation in LA and RA by endocardial ablation of GP may increase sinus rate and improve symptoms in non-elderly patients with symptomatic longstanding SB. Introduction Sinus bradycardia (SB) is not unusual in non-elderly individuals, most of whom are asymptomatic. Pacemaker implantation has been prove
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Biomedical Science and Research Journals | False Negative PCR Tests for SARS-COV-2 – the Elephant in the Room

  False Negative PCR Tests for SARS-COV-2 – the Elephant in the Room Abstract Introduction:  Without criterion standards, clinicians have often been at a loss to interpret the meaningfulness of negative SARS-COV2 PCR testing in admitted patients. We provide a compelling epidemiologic analysis to ascertain an estimated false negative rate in an institution in New York City which experienced a surge early pandemic in the Bronx N.Y. Methods:  Using admitted historical controls from March 2019 as well as current patients analyzed from the initial surge of cases in NYC we used a logistic regression to determine the expected mortality rate in the Covid Negative, compare to the controls, and use an algebraic mixture equation to determine the false negative rate that could be responsible for the observed high mortality rate among the Admitted Covid test negatives. Results:  Unadjusted Mortality observed in March 2019 admissions 189/7462 (2.5%). Mortality in March 2020 CN 68/698 (9.7%). CP (417
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Biomedical Science and Research Journals | Use of Osmolytes For Improving Abiotic Stress Tolerance in Brassicaceae Plants: The Case of Proline

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  Use of Osmolytes For Improving Abiotic Stress Tolerance in Brassicaceae Plants: The Case of Proline Abstract Osmolytes are low-molecular-weight compounds like amino acids, tertiary sulphonium and quaternary ammonium compounds, sugars and polyhydric alcohols. They are accumulated in the plant cytoplasm so as to balance the osmotic potential of the Na+ and Cl− accumulated in the vacuole. The osmolytes accumulation advantages are that they keep the main physiological functions of the cell active, the induction of their anabolism is controlled by environmental cues, and they can be synthesized at all developmental stages. In addition, osmolytes have crucial functions in protecting subcellular structures and in scavenging reactive oxygen species. This mini-review discusses the use of osmolytes in Brassicaceae plants and their role in osmoregulation and osmoprotection, using the proline as a model. Increasing the osmolyte content in plants is an interesting strategy to improve the growth a
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Biomedical Science and Research Journals | Suboptimal Birthweight and Adult Cardiometabolic Disease: The HPA-Axis Link

  Suboptimal Birthweight and Adult Cardiometabolic Disease: The HPA-Axis Link Introduction Suboptimal birthweight (<10 th  percentile, >90 th  percentile) has a well-established relationship with several adult cardiometabolic risk factors, including obesity, dyslipidaemia and elevated Blood Pressure (BP) [1]. Over the past three decades, several animal studies have investigated this relationship. Together, these studies have shown that in sub-optimally grown offspring, adaptive changes occur in key organ systems to maximize chances of ex-utero survival [2]. Unfortunately however, these early life adaptations to organ structure and function render suboptimally grown offspring vulnerable to chronic disease later in life [3]. This concept is known as the Developmental Origins of Health and Disease (DoHAD) hypothesis, and provides the broad mechanistic framework underpinning the relationship between adverse early life exposures and chronic disease in adulthood [2]. The hypothalamic p
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