BiomedGrid

  Identification and Molecular Characterization of the Most Common Types of Beta Thalassemia Mutations in Sudanese Patients Abstract Thalassemia is a common inherited disorder among humans, and they represent a major public health problem in many areas of the world. The spectrum of mutations varies significantly between different geographical regions; only a few common mutations of β-globin cause β-thalassemia in each population. This is a cross-sectional study conducted in Sudan, among 61 known beta thalassemic patients arrived at public health hospitals of Khartoum State, during the period of July 2017 to July 2019. The study was aimed to detect the most common types of mutations in Beta Thalassemic Sudanese patient in Khartoum State. Blood samples from 61 beta thalassemic patients were analyzed to detect the most common types of mutations in Beta Thalassemia using PCR assay. the frequency of adults (>18 years) was 45 (73.8%), and 16 (26.2%) were Children (<18 years)., The ...

  Nanomedicine: Development and Challenges in Cancer Treatment Abstract A brief review of the literatures on development and challenges associated with success of nanomedicine for cancer therapy is presented. Nanomaterial shape, size and characteristics plays an important role in an effective treatment. The chemotoxicity, non-targeted and non-uniform heating in tumors were the major drawbacks in nanomedicine assisted hyperthermia, however recent developments in nanomaterials possessing multifunctional characteristics enabled better diagnosis and helped in the treatment of cancer. Keywords:  Nanoparticles; Gold nanoparticles; Liposomes; Carbon nanoparticles; Fluorescence imaging; Quantum dots Introduction Radiation therapy has been successfully applied in clinics for cancer therapy; however, its success rate is limited to ~50% due to non-responsive cancer cells for therapy alone and it’s very expensive. Chemotherapy uses chemicals to kill or stop the growth of cancer cells howe...

  Fermented Brown Rice and Rice Bran with  Aspergillus Oryzae  as A New Promising Agent for Cancer Prevention Minireview Fermented brown rice and rice bran with Aspergillus (A) oryzae (FBRA) is a food manufactured by fermenting a mixture of brown rice and rice bran with A. oryzae. The fermentation is proved to increase antioxidant phytochemicals. FBRA prevented carcinogeninduced carcinogenesis in 7 animal models. FBRA also acted against spontaneous development of neoplasms in 3 animal models. FBRA is suggested to be a new promising agent for prevention of human cancers. It has been recognized that dietary factors play an important role in prevention of occurrence of human cancers. Epidemiological studies have shown that high intake of fruits, vegetables and cereal foods decrease the risk for the occurrence of cancers in different organs. Rice is one of the major cereals, and is the most consumed food worldwide, particularly in Asian countries. Rice seeds and rice bran con...

  Lychee Honey Accelerates Antibacterial Efficacy of Penicillin and Amoxiclav Against Gram-Positive Bacteria in Libya Abstract Background:  The world has left very few of its last line agents to fight against the common infectious diseases due to the rapidly growing phenomenon of bacterial resistance. The present study was thus aimed to rejuvenate the penicillin and amoxicillin-clavulanic acid among the resistant antibiotics supplemented by Lychee Honey as a natural agent. Methods:  The study was performed against four-gram positive bacteria where the standard antibiotics and Lychee honey were applied to assess their individual efficacy. Afterwards, the standards were conjugated with lychee honey to evaluate the boosted potential of the combinations. Zone of inhibition, percentage inhibition, minimum inhibitory concentration and minimum bactericidal concentration were observed in this regard. Results:  Data suggested that against all four bacteria, lychee honey alone...