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Biomedical Science and Research Journals | Evaluation of Antidiarrheal Activity of Aqueous Leaf Extract of Anogeissus leiocarpus on Castor Oil-Induced Diarrhea in RatsMice

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  Evaluation of Antidiarrheal Activity of Aqueous Leaf Extract of Anogeissus leiocarpus on Castor Oil-Induced Diarrhea in Rats Abstract Diarrheal diseases are a major public health problem in developing countries. Anogeissus leiocarpus (DC.) Gill. & Perr (Combretaceae) is used in Africa and particularly in Cameroon for the empirical treatment of diarrhea. The present study was undertaken to evaluate the effects of aqueous extract of leaves of Anogeissus leiocarpus on castor oil-induced diarrhea in rats. Diarrhea was induced by administering 10 mL/kg body weight of castor oil orally to male rats. The determination of effective doses was made by assessing the weight and frequency of diarrheal stool of different doses of the extract (25 mg/kg, 50 mg/kg, 100 mg/kg, 200 mg/kg and 400 mg/kg). The effects of the aqueous extract of Anogeissus leiocarpus on intestinal transit were determined with an activated charcoal meal in rats. The effects of the aqueous