BiomedGrid

  Relation of a Pulse Transit Time to the Blood Pressure in Bifurcated Cardiovascular Networks Abstract Recent developments in cardiovascular mathematics allow to simulate blood flow in the entire circulatory network or any isolated cardiovascular subsystem. Providing measurements of a Pulse Transit Time (PTT), or the averaged value for the Pulse Wave Velocity (PWV), the patient specific computational model can create personalized transfer functions, converting distal measurements to the set of cardiovascular biomarkers. The latter has a potential to build the feasible foundation for the personalized continuous self-monitoring of cardiovascular health based on portable mobile and wearable applications. Nevertheless, although being of a great interest, an accurate and reliable PTT-based Blood Pressure (BP) estimation barely exists nowadays due to the complexity of a BP regulation in a human body. In this paper we concentrate on a physics based computational modelling to assess inter...

  Future of Biotech Equipment/Medical Device Research & Development: A Case for Redemption of the Neglect Introduction The global healthcare industry is undergoing a progressive transformation at a rapid pace. Ground breaking innovation across multiple fields including biotechnology, pharmaceutical and medical devices is driving this transformative journey, the main outcome of which is improved patient health and decreased cost burden resulting in enhanced quality of life. Small molecule drug development and advances in bio therapeutic formulations by various pharmaceutical and biotechnological companies respectively, either alone, or in collaboration with dedicated research groups in academia tend to garner the majority of government and non-governmental funding. However, a critical area of biomedical research that lags behind in comparison with its peers in this category are biomedical devices that are also an integral part of patient therapy. While this disparity is most evi...

  Will the Modern Technology ever Catch up with the ‘God’s Formula’ of Dietary Fiber? Opinion The history of dietary fiber began back in ancient Europe during Hippocratic era, where function of wheat bran was already known as a laxative. The development of powdering system in France during 18 th  century has led to a debate between white bread and brown bread. However, this debate was based solely on their nutritional values, and depended on the opinions of food manufacturing companies and certain dietitians, thus the significance of dietary fiber was not well explored. In the USA,  Kellogg  et al. [ 1 ] had found a great interest in the function of wheat bran and advanced the scientific research on it. During the process, Williams et al. [ 2 ] have found that although cellulose, hemicellulose and lignin are degraded in digestive tracts, they increase the amount of stool and softens it. Also,  McCarrison  [ 3 ] concluded from the research that eating whole-...

  Real-Time Three-Dimensional Reconstruction of Intraoperative Liver Surface Based on Structured Light Technique Mini Review The incidence of liver tumor is increasing year by year, and liver tumor resection is a routine operation for liver lesions. Liver tumor resection is more difficult than general surgery, mainly reflected in the liver itself is easy to deform, vascular density, complex structure and other aspects [ 1 ]. If the three-dimensional information of the liver surface can be obtained in real time during the operation, it will be helpful for doctors to observe the cutting status of the liver surface in real time and avoid the possibility of being cut by mistake to a large extent. Clinical studies have shown that failure to accurately locate the focal point of the liver during surgery, to obtain real-time three-dimensional information on the liver surface and to plan the surgical path are the most important reasons for the failure of such surgery [ 2 ]. Traditional live...

  New Understanding of Fanconi Anemia Signaling Network upon Studying FANCD2 Abstract The Fanconi Anemia (FA) pathway is activated upon replication stress and DNA damage. With the accumulated studies, this pathway has emerged as a fundamental signaling network to defend genome stability. The Fanconi Anemia complementation group D2 protein (FANCD2) sits at the center of the pathway, orchestrating many players to prevent our genome from going awry, leading to diseases including cancer. Here, we highlight recent advances in our understanding of FA signaling, emphasizing on a rarely known form of FANCD2, FANCD2-V2. Fanconi Anemia Fanconi anemia is a rare genetic disease, characterized by developmental and physical abnormalities, bone marrow failure and increased cancer susceptibility [ 1 ,  2 ,  3 ,  4 ,  5 ,  6 ,  7 ,  8 ,  9 ]. The majority of children with FA are likely to develop myelodysplastic syndrome or acute myeloid leukemia (AML), while...