Showing posts from December, 2022

Biomedical Science and Research Journals | Happy Christmas


Biomedical Science and Research Journals | Experience Design for Kids: Phygital Product for Augmented Pedagogy

  Experience Design for Kids: Phygital Product for Augmented Pedagogy Abstract The paper aims to highlight the active role that some tools have assumed within the playful activity of today’s children. It is intended to underline, how the connection of the digital world with the world of toys allows to expand the games from traditional ways to create new possibilities of play and active learning for an augmented pedagogy. Keywords:  Augmented Pedagogy, Playful Experience, Phygital Product, Kid-Centered Design, Digital Education, Edutainment, STEM, Smart Toys, Design for Kids Introduction One of the major differences between today’s children’s play and that of the past is the strong presence of tools to facilitate or influence the action of the game. Obviously, children have always played as far as they could, yet the ways, the gestures, the objects of their games have always been related to their culture and social conditions. But nowadays the awareness of the status of the game as a dy

Biomedical Science and Research Journals | Using Nanomedicine to Drive Advances in Cancer Immunotherapy: A Mini Review

  Using Nanomedicine to Drive Advances in Cancer Immunotherapy: A Mini Review Abstract Immunotherapy has shown remarkable clinical success and holds tremendous promise for enhancing cancer treatment Outcome. However, therapeutic complete responses are limited to a subset of patients selected cancers and treatment outcome can trigger severe toxicity due to systemic activation of the immune system. Here, we discuss the opportunities to overcome these drawbacks by combining immunotherapy with nanomedicine using tailor-made nanoparticles (NPs) to increase cancer selectivity and minimize toxicity. Further, we provide directions on requirements and discuss advantageous characteristics of using calcium carbonate as core component of such NPs. Keywords:  Nanoparticles, Cancer Immunotherapy, Drug delivery Mini Review In recent years, immunotherapy with so-called checkpoint inhibitors that (re)activate tumour-directed T cell responses has induced complete remissions in a subset of patients, conc

Biomedical Science and Research Journals | Rural Clinic Productivity

  Rural Clinic Productivity Opinion Rural hospitals face difficult financial times with rising costs and increasing demand from a low income and poorly insured population base. Many have gone bankrupt and closed in recent years although they are critical to their communities. Like much of healthcare, they are increasingly dependent on outpatient clinic services since specialty inpatient services are often limited in rural locations. In 2019 and 2020 I conducted a survey of hospital outpatient clinics focusing on productivity of their operations at over a dozen California Critical Access Hospitals (CAH). The survey consisted of the following steps: I. Identifying the proper contact at each CAH, generally the CEO, and have a discussion of the scope and focus of the survey. II. Arranging a one-day site visit to the specific clinic identified by the CAH. In most cases this was their primary care outpatient clinic. The clinic staff were to be notified in advance of our visit and certain cli

Biomedical Science and Research Journals | Justifying the Antidiabetic Ethnomedicinal Claim of Massularia acuminata Through Its Antihyperglycaemic Activity

  Justifying the Antidiabetic Ethnomedicinal Claim of  Massularia acuminata  Through Its Antihyperglycaemic Activity Abstract Diabetes mellitus is becoming the third ‘killer’ of mankind, after cancer, cardiovascular and cerebrovascular diseases, because of its high prevalence, morbidity and mortality. The antihyperglycaemic activity of the leaf of  Massularia acuminata  that is used ethno medicinally in Nigeria in the management of diabetes mellitus was investigated is this study to justify its antidiabetic folkloric claim. Ethanol leaf extract of the plant at 100,200 and 400mg/kg was investigated for its antihyperglycaemic effect in glucose-induced hyperglycaemic rats using glibenclamide (5mg/kg) and 1% Tween 80 in normal saline as positive and negative controls, respectively. Anti-hyperglycaemic activity-directed purification of the ethanol leaf extract of the plant in glucose-loaded rats, led to the isolation and characterisation of acuminatoside by comparing its spectral data with