BiomedGrid

  Deciphering Interactive Associations of Antiviral and Electron-Shuttling Characteristics of Flavonoid Compounds for Antiviral Drug Development Abstract In face of the 2020 coronavirus COVID-19 pandemic, exploration of feasible medicines and effective medication is of course a top-priority issue to save lives worldwide. This study focused on antiviral properties of flavonoids to decipher synergistic interactions with electron-shuttling characteristics for possible herbal medication in clinical treatment. In fact, the numbers and relative positions of hydroxyl groups all strongly influenced antioxidant activities of flavonoid compounds. In particular, ortho-polyhydroxy benzene-bearing aromatics seemed to trigger antiviral characteristics to be expressed. Prior studies mentioned that ortho and para-polyhydroxy benzene-bearing aromatic structure could exhibit reversible and stable electron-shuttling characteristics. This comparative study suggested the rationale of initiatives for se...

  ED Acuity in Patients with Respiratory Complaint During the COVID-19 Pandemic: A Single-center Experience Abstract Introduction:  In response to the novel coronavirus (COVID-19) pandemic, “shelter-in-place” (SIP) orders were implemented across the country to control the spread of this respiratory infection and decrease the burden on hospitals in the United States. Our objective was to assess changes in emergency department (ED) volume and acuity in patients with a respiratory complaint in a single center in Los Angeles county, California during the pandemic with respect to the SIP order. Methods:  We conducted a single-center retrospective review that included de-identified data from patients presenting to the ED with a respiratory complaint from December 2019 to May 2020. We examined the monthly distribution of triage levels, as defined by the Emergency Severity Index, as an approximation of general acuity and resource utilization. We also examined the monthly ED volum...

  Performance of Commercially Antibody-based assays for Covid-19 Detection Abstract The ongoing SARS-CoV-2 pandemic caused by novel coronavirus has become a threat to international public health. To tackle this pandemic reliable and rapid immunodiagnostic strategies are required. This study will briefly review the antibody diagnosis methods and recent clinical studies in this regard. The sensitivity and specificity after two weeks are considered to examine the late stages response of the disease. Among current studies on serology testing, 27 recent publications used commercial assays to diagnose IgM and IgG against SARS-CoV2 are discussed in this paper. A total of 54 kit-testing for antibodies, 20 are based on ELISA principles using serum or plasma samples with a sensitivity range of 55.6 % and 100% for IgG and between 77.3 % and 82.7 % for IgM. The specificity for both IgG and IgM ranges between 87.5 % to 100%. Twenty-seven kits are using lateral flow platforms and thirteen kits u...

  Ameliorative Effects of Dried and Germinated Fenugreek Seeds on Kidney Failure Induced by Gentamicin in Male Mice Abstract Gentamicin is an aminoglycoside antibiotic widely used against Gram-negative microorganisms. Nephrotoxicity is the main limitation to its therapeutic efficacy. The aim of work was to investigate the role of dried and germinated fenugreek seeds as a potent antioxidant against the nephrotoxicity and oxidative stress in the kidney. Male Swiss albino mice were divided into The animals were injected intraperitoneally with distilled water. The animals were intraperitoneally injected with gentamicin. The animals were orally received fenugreek ( Trigonella foenum -graecum ) The animals were orally received germinated fenugreek. The animals were intraperitoneally injected with gentamicin simultaneously with fenugreek ( Trigonella foenum -graecum ). The animals were intraperitoneally injected with gentamicin simultaneously with germinated fenugreek. All the treatments ...

  Beliefs and Practices During Antenatal and Postnatal Period Among the Host Communities in Cox’s Bazar, Bangladesh Abstract Bangladesh, one of the affected countries with refugee, faces the challenge to provide health care especially maternal care to the host communities. This paper presents maternal care related thoughts and practices in the host communities in Ukhia of Cox’s Bazar. We collected data using mixed method approach including a cross-sectional survey and semi-structure interviews. Using a probability sample, we selected mothers with infants (n=588) living in the host communities of Ukhia sub-district. We also conducted forty-two in-depth semi-structured interviews among the currently pregnant women who had also previously given births (n =21); and recently delivered women (n = 21). The survey found one quarter of the recently delivered women received at least four antenatal care visits and 28 percent women received at least one postnatal care visit. Seventy four perce...