BiomedGrid

 

  PASH Syndrome: Comparing Pathogenic Mechanism of Pyoderma Gangrenosum, Acne and Suppurative Hidradenitis Abstract PASH syndrome is a recently described autoinflammatory disease, consisting of pyoderma gangrenosum (PG), acne and hidradenitis suppurativa (HS). We report a new case of PASH syndrome, highlighting the features of the rare condition. For a better understanding of each of the three diseases and of the PASH syndrome, we reviewed the common and the particular aspects of these pathologies, looking from different angles of inflammation mechanisms. Among the approached topics, we discussed about: increased production of interleukin-1 (IL1) and of other cytokines, altered matrix metalloproteinases expression, multiple roles of neutrophils, genetic profiling and inflammatory infiltrates. As far as we know it is the first time we note the similarities and differences of pathways beyond the neutrophils mediated cutaneous manifestations present in PASH, PG, HS and acne. Our findi...

  Mitochondrial Dysfunction in Neurodegenerative Disorders and Atherosclerosis: Pathophysiological Mechanisms and innovative Protocol Towards an Elegant New Era Of Health Introduction The energy plants of the  human being are composed of trillions of  mitochondria which is  semi-autonomous ,double membrane-bound cellular  organelles that is in charge of generating most of the chemical energy needed to operate the cellular  biochemical reactions in the human body. The sizes of mitochondria vary from 0.75 to 8 mm depending on the cell type, cell cycle stage, and intracellular metabolic state . These organelles make up as much as 10% of the cell volume but responsible of producing  90% of the human needs of  energy. Mitochondria can be divided into four functional areas, the mitochondrial outer membrane (OMM), mitochondrial membrane space, mitochondrial inner membrane (IMM), and mitochondrial matrix. The IMM is rich with various membrane proteins and...

  How to Get More Transparency in Animal Experiments - Participation in CIRS-LAS Opinion Considering the current state of science, the use of animals in experimental purposes cannot completely be replaced by i.e. chip technology or mathematical approaches. In Europe, every year about 10million laboratory animals are still used in experiments, for teaching, or animal breeding for scientific purposes. Transparency and reproducibility are important tasks we must focus on laboratory animal science. In our everyday work we are faced with critical incidents, near accidents, or comparable negative events. The only way to deal with it is to recognize it, to analyze it, to discuss about it, and to find possible approaches to avoid repeating unsuccessful animal experiments. The task to use 3R guidelines or other animal welfare related resources is more and more asked to fulfill the responsible work with laboratory animals according the 3R principles [1,2]. Regarding the high number of public...

  More Questions Than Answers: Factors Affecting Human Gender Identity and Sexual Orientation: A Mini Review Abstract One’s gender identity and sexual orientation are determined by a combination of factors. These include a genetic predisposition, hormonal activity during fetal and neonatal life and sensitive periods during childhood when the capacity for establishing sexual preferences are subject to influences from both family and society. Animal studies have shed some light on the situation, as also have anomalies that have arisen during human development. However, there is still much to be learnt about how this takes place. Introduction Currently there has probably never been more interest in brain development and how one’s genetic makeup, hormones and the environment, acting during limited critical periods, affect one’s future gender identity, thoughts, emotions and consequent behavior. However, the topic has now become highly politicized and it is thus a difficult time to expr...