BiomedGrid

  Potential Role of ACE2 Inhibition in COVID-19 Severity Opinion In addition to being the entry point for SARS-CoV-2, ACE2 may play a role in the disease progression of severe COVID-19 cases. The five pre-existing conditions that currently lead to the highest COVID-19 mortality rates have also been linked to altered ACE2 activity and the related renin-angiotensin system. Since there are multiple ways in which SARS-CoV-2 could be inhibiting ACE2, it is very possible that ACE2 inhibition is the reason for this connection. Due to the connection between ARDS, a common cause of death in COVID-19 patients, and ACE2, it is also possible that this can lead to COVID-19 severity in some cases. Angiotensin-converting enzyme 2 (ACE2) is a glycoprotein that converts angiotensin II (Ang II) into angiotensin 1-7 (Ang 1-7) and is an important component in the renin-angiotensin system (RAS) [1]. The RAS has many functions in the body, most of which are related to vascular function [1]. Consequently, th

  Impact of SARS-CoV-2 On St-Elevation Myocardial Infarction (STEMI) Introduction Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV 2) pandemic originated from Wuhan, China, in December 2019 and rapidly spread throughout the globe [1]. Currently, SARS-CoV 2 has resulted in an enormous number of deaths worldwide [2,3]. Based on the WHO report on 28 April 2020, almost 3 million confirmed cases of COVID-19 have been identified, and nearly 7% of them have died due to disease and its complications [4]. Regarding the catastrophic impact of COVID-19 on human well-being, investigation of its manifestations, complications, and appropriate treatment has become the most concerning issue in the World Health Organization recently. Elders, especially those with underlying diseases, including chronic bronchitis, congestive heart diseases, and diabetes, are more susceptible to COVID-19 complications [5]. Various types of complications with different prevalence have been reported in literature

Is Bevacizumab a Direct Cause of Osteonecrosis of the Jaw like Bisphosphonate? Abstract In 2014, the American Association of Oral and Maxillofacial Surgeons (AAOMS) published a revised position paper on osteonecrosis of the jaw in which cases caused by drugs other than bone resorption inhibitors, such as bevacizumab (an angiogenesis inhibitor), were labeled medicationrelated osteonecrosis of the jaw (MRONJ). Bevacizumab (Avastin) binds to endothelial growth factor (VEGF) preventing its attachment to receptors located on the surface of endothelial cells, thus inhibiting angiogenesis. Although the first case of ONJ caused by bevacizumab was described in 2008, clinical cases of ONJ have since been described in which the use of bevacizumab is the only clear risk factor. This mini-review aims to summarize ONJ associated with bevacizumab, which was first recognized by the AAOMS in 2014. Introduction Osteonecrosis of the jaw (ONJ) is a bone disorder in which bone devitalization results from h

  Evidence based study of Hypoglycemic Potential of Bitter Melon Peptide Abstract Momordica charantia ( M. charantia ), commonly referred to as bitter melon was received much attention for its anti-diabetic properties in recent years. The aim of this review was to discuss the bioactive peptides in bitter melon through their  in vitro ,  in vivo  and clinical studies for diabetes. Research showed that bitter melon peptides acted as the α-amylase or α-glycosidase inhibitor delayed the absorption of glucose from carbohydrates. Another noteworthy mechanism was the glucose intake regulation by insulin-like activities to enhanced insulin receptor kinase activity which activated IR signaling transduction pathway, resulted the translocation of glucose transporter 4, and uptake of glucose to cells. The remarkable effect of bitter melon peptide (mcIRBP-19) in patients with diabetes was also reported in the clinical study. This study summarized the scientific evidence of bitter melon peptides in

  New Optical Tools for Spectral Diagnostics of Liquid Solutions Abstract Three new optical devices has been design and constructed for the operative diagnostics of medical, biological and water solutions using state-of-the–art technology of optical inverse tasks solution in wavelength range from 350nm to 780nm. The structures of optical devices have the elements for the assessment of optical properties of liqueds and software for the concentration evaluation of chemicals in the solutions. One of the functions optical devices is recognition of solutions to define their classes using a database of spectral standards. The using optical devices in the expedition conditions in the hard-to-reach regions when there no exists chemical laboratory for operative analysis can be unique possibility to know a solution quality. One of such situations is mission to Mars. This paper represents results of optical diagnostics of the water objects in South Vietnam and Siberia when the water quality of th

Advanced Applications of Biomaterials Based on Alginic Acid Abstract Alginic acid, also known as algin or alginate, is a natural carbohydrate, which is derived from marine brown algae, as well as some microorganisms. It can be used in various applications. In particular, alginate has shown great potential in the areas of wound healing, drug delivery, in vitro cell culture, and tissue engineering, allowing the categorization of it as a promising biomaterial, or a basic component of other biomaterials. The unique characteristics of alginic acid, such as the biocompatibility, the mild required gelation conditions, the low toxicity, the relative low cost and the simple modifications, allow the development of alginate hydrogels, and alginate derivatives with enhanced properties. The aim of this review, is to present an overview of the properties of alginate, shedding light on the current and potential applications and suggesting new perspectives for future studies. Introduction Innovative b