BiomedGrid

  The Response of the Hellenic 3D-Printing Community over the COVID-19 Pandemics: The Success Story of the Hellenic Mediterranean University Abstract By the February of 2020, humanity has to come across with a global health emergency. The corona virus, formally defined as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been declared a pandemic from the World Health Organization (WHO). No one could imagine how the disease’s spread could affect the people’s life over the following months. The uncontrolled outbreak of COVID-19 caused a lack of Personal Protective Equipment (PPE)-Medical Devices in hospitals worldwide. Industry sector and supply chain was not able to cover all needs in PPE. In this situation, hospitals’ personnel have been working in the front line without any protection. There is where the “3D COVID” project comes. Many companies, hobbyists and academic entities started using their 3D Printers to produce PPE and/or Medical Devices (such as respiratory...

  Evaluation of The Pressure Ulcers after Using Barrier Cream in Intensive Care Unit Introduction A pressure ulcer (PU) is specified by National Pressure Ulcer Advisory Panel (NPUAP) as localized cutaneous or subcutaneous tissue damage that occurs on bone protrusions whether alone or in combination with shear stress [1]. Clinicians often use a four-grade system as defined by NPUAP for consistency in diagnosing and treatment; Grade 1 non-blanchable erythema with intact skin, Grade 2 partial skin loss of the dermis, Grade 3 full thickness skin loss with exposed dermis and Grade 4 deep tissue loss and injury exposure of bone, tendon and muscle [1]. Pressure ulcers are caused by multiple factors such as immobilization, malnutrition, advanced age, urine and/or faeces contamination, overhydration and friction [2]. In intensive care units (ICUs) because of mechanical ventilation, limited immobilization, widespread use of anesthetic, sedative and muscle relexant drugs and circulatory venti...

  The Porcine Experimental Model for Oocyte Cryopreservation by Vitrification Abstract Pigs have anatomical-physiological similarities with the human in several aspects, mainly in the reproduction function, which is of great interest in this review. However, in oocytes, there are differences between both species, impacting the vitrification success. For example, porcine oocytes have higher intracellular lipid content than women oocytes, affecting cryoprotectant permeability and increasing ice crystal formation. Despite these differences, the porcine model has been important for the development of assisted reproduction technologies in humans, as well as in the genetic improvement of livestock. Importance of the Porcine Experimental Model Since its domestication 7000-9000 BC, the porcine species have been historically significant as a food source for humans. In the 1950s, it began as a possible experimental model in biomedical research. Some of the most important events are the isola...

  Genosensor Study for Fetal Cell-Free DNA Detection Abstract β-Thalassemia is one of the most monogenic autosomal recessive disorder characterized by defective production of the hemoglobins β-chain. Definition of the β-globin genotype is necessary for genetic counselling in the carriers, and for predicting prognosis and management options in the patients with thalassemia. Genetic analysis of β-thalassemias routinely relies on polymerase chain reaction (PCR) and gel electrophoresis. The aim of this study is to develop a new procedure, a nanopolymer-based Lab-on-a-chip based biosensor for the real-time multiplex analysis of β thalassemia mutations from Cell-Free DNA. In this study, biospecific interaction analysis (BIA) employing quartz-cristal microbalance (QCM) and biosensor technologies was applied to the analysis of multiple mutations of the human β-globin gene. To this aim, large target polymerase chain reaction products were immobilized on genosensor electrode and then probes ...

  Additive Manufacturing in Land Vehicle Industry Abstract Additive manufacturing has been gaining more importance in the recent years for diverse applications due to its various advantages like mass customization, enabling very complex geometries, weight reduction, lead time and cost advantage for small volume production. Additive manufacturing has become an almost mature technology group in biomedical applications for different materials. However, aerospace and defense industries are still investigating its feasibility for a wide range of applications due to strict and demanding requirements. The land vehicle industry demands mainly small series and cost efficient production of parts to be used in arduous conditions in battlefield. Even more importantly, the short lead time and the possibility to produce at the battle field makes the additive technologies significant for the land vehicle industry. This paper will focus on the road mapping and prioritization of additive technologi...