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Biomedical Science and Research Journals | Multiple Endocrine Neoplasia Type 2B Due to the M918T Mutation de Novo at Algiers

  Multiple Endocrine Neoplasia Type 2B Due to the M918T Mutation de Novo at Algiers Summary Multiple Endocrine Neoplasia type2B (MEN2B) associates Medullar Thyroid Cancer (MTC), pheochromocytoma, gastrointestinal disorders, marphanoid face, and mucosal multiple ganglioneuroma. The MEN2B belongs MEN2 which are hereditary diseases related to mutations of RET proto-oncogene. Genotypic analysis is indicated in any case MEN2B and involved the detection of mutations in the RET gene. Samples of two patients aged 23, 22 and 20 years of 03 different families diagnosed MEN2B were analyzed. The genetics analysis also covers 10 members of the 03 families. It was realized, after DNA extraction from whole blood by the method to salts, by amplification of exons by PCR followed by sequencing on Applied Biosystems ABI 3130 and concerned the exons 15 and 16. Germline mutation M918T, located at exon 16 in heterozygous form, was found in the 03 index cases MEN2B. The discovery of this mutation, highly spe
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Biomedical Science and Research Journals | Lost in Translation? From Conventional Scoring Tools to Modern Data-Driven Risk Assessment in Critical Care Medicine

  Lost in Translation? From Conventional Scoring Tools to Modern Data-Driven Risk Assessment in Critical Care Medicine Abstract High-resolution, longitudinal health data became widely available in intensive care units in the past years. Patient risk assessment, however, is still primarily based on conventional scores that take into account only a few parameters taken at single time points, which frequently causes inaccurate predictions in the clinical practice. Likewise, the contribution of AI-approaches remains sparse, as current machine learning models are inherently difficult to deduce and even impressive results rarely contribute to disease understanding. This review focusses on the limitations of conventional risk scores, and on recent developments and challenges of novel, data-driven assessment tools. Keywords:  Critical Care Medicine, Risk Prediction, Decision Support, Machine learning, Artificial Intelligence Introduction Intensive care medicine is a fast-paced medical field wh
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AJBSR FAQs: Key Answers to Biomedical Research and Publishing Questions

 AJBSR FAQs: Key Answers to Biomedical Research and Publishing Questions Q: What are the Manuscript Guidelines in Open Access AJBSR? A: The Manuscript Guidelines for the American Journal of Biomedical Science & Research (AJBSR) provide detailed instructions for authors preparing their submissions. The manuscript should be structured as follows: a Title Page including the manuscript title, authors' names, affiliations, and contact information for the corresponding author; an Abstract summarizing the research in 150-300 words with key findings; 3-6 Keywords reflecting the main topics; an Introduction outlining the background, reasons, and objectives; Materials and Methods detailing the study design and procedures for replication; Results presenting findings with appropriate tables and figures; a Discussion interpreting the results and their significance; a Conclusion summarizing main findings and implications; Acknowledgments for contributors, funding sources, or institutions;
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Biomedical Science and Research Journals | Cellular Mechanisms of Chromosomal Damage in Fish Models During the Early Steps of Carcinogenesis. Does Gender have an Effect?

  Cellular Mechanisms of Chromosomal Damage in Fish Models During the Early Steps of Carcinogenesis. Does Gender have an Effect? Abstract Since fishes are widely used as model species in understanding cellular mechanisms of many human diseases such as carcinogenesis early steps, and to test the cellular potential cellular impairment of xenobiotics such as emerging pollutants, it appears of great interest to obtain strong reliable data from fish experimental researches. In humans, the loss of chromosomal integrity, detected by the increase of micronucleus frequency, was demonstrated to be associated with early events in carcinogenesis. On the other hand, the loss of chromosomal integrity was found to be associated most frequently with sex chromosomes. We should wonder if cellular mechanisms promoting chromosomal damage in fish are influenced by the gender. This brief work tries to analyze this aspect before transferring any conclusion from fishes to humans. Fish Model in Human Diseases
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Biomedical Science and Research Journals | Research of Gestational Risk by Primary Health Care Professionals in Brazil

  Research of Gestational Risk by Primary Health Care Professionals in Brazil Summary In Brazil, the reduction of preventable causes of maternal mortality is a major challenge for health professionals. The Ministry of Health recommends the assessment of gestational risk in prenatal consultations. In this sense, a research is being carried out with the purpose of verifying how the assessment of gestational risk is made by nurses and doctors, who are the professionals who perform prenatal care. The municipality of Corumbá, Mato Grosso do Sul, was chosen to carry out the research, as it is one of the places with high indicators of maternal mortality. Data collection consists of filling in a checklist with demographic, social, environmental and health variables, all related to high gestational risk and that guide the actions to be taken to avoid complications that may lead to maternal death. This survey of how gestational risk assessment is carried out will provide subsidies to improve car
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Biomedical Science and Research Journals | How to Reduce the Main Risk of Menopausal Hormone Therapy (MHT, HRT, HT)

  How to Reduce the Main Risk of Menopausal Hormone Therapy (MHT, HRT, HT) Summary Most societies with interest in the field of estrogen/progestogen-therapy in peri- and postmenopausal women have now agreed to give this important area of gynecology the name “Menopausal Hormone Therapy” (MHT) instead of “hormone replacement therapy” (HRT) or “hormone therapy” (HT). The different terminology includes different assessments, different rationales, of this therapeutic area. There remains still some confusion since the definition of “menopause” is the “last period”, but indeed this treatment is offered not only during the time of or after the last period but for example also is urgently needed for women with primary ovarian insufficiency (POI) (for example after chemotherapy) or after oophorectomy, i.e. during a long period in womens’ life. Thus, the old term ‘HRT’ is also still in use, even the usual treatment of peri- and postmenopausal women should not be seen as a “replacement” (R), but r
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