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Biomedical Science and Research Journals | Lung Inflammatory Myofibroblastic Tumor Carrying TGF -ROS1 Fusion: About a Case

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  Lung Inflammatory Myofibroblastic Tumor Carrying TGF -ROS1 Fusion: About a Case Abstract Background:  Inflammatory lung pseudotumors are extremely rare. Their pathogenesis is controversial, their diagnosis is often difficult, and their clinical behavior can be unpredictable. Case présentation:  This is a 48-year-old patient hospitalized for management of an intracranial hypertension syndrome whose radiological assessment was in favor of metastatic brain lesion with primary pulmonary origin, the biopsy with anatomopathological study posed the diagnosis of ‘’ an inflammatory myelofibroblastic tumor associated with a TGF-ROS 1 fusion ALK-negative, the patient benefited from treatment with a targeted therapy based on crizotinib with good clinical response, in particular the regression of symptoms and radiological response, patient currently still under treatment. Conclusions:  Immunohistochemistry for ROS1 helped to support the diagnosis of a subset of ALK negative inflammatory myofibrob
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Biomedical Science and Research Journals | Thrombosis, an Important Piece in the COVID-19 Puzzle – From Pathophysiology to Therapy

  Thrombosis, an Important Piece in the COVID-19 Puzzle – From Pathophysiology to Therapy Abstract Background:  A lot of data about COVID-19 was already published but this is only a part of the pandemic puzzle pieces. Once we will have all the pieces together, we will be able to successfully treat this disease with so many challenges. This infectious disease has a high thrombogenic potential. The study aims to review published data about COVID-19 associated thrombosis, from pathophysiology to treatment and the role in patient’s evolution. Data sources: We have searched for articles and studies published in online. Platforms:  MEDLINE/PubMed database, Google Scholar, ScienceDirect, Wiley Online Library, Nature Public Health Emergency Collection. Results: We have found numerous articles regarding the COVID-19 infection. We selected only those focused on the thrombosis. D-dimers had predictive value in identifying thrombosis and high level had correlated with the severity of the infection
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Biomedical Science and Research Journals | Can Climate and Environmental Factors Putatively Increase SARS-Cov2 Transmission Risks?

  Can Climate and Environmental Factors Putatively Increase SARS-Cov2 Transmission Risks? Abstract After the identification of the first SARS-COV-2 infected cases in China, the virus was rapidly disseminated among the distinct continents and the COVID-19 pandemics was announced by the WHO in March 2020. Over time, the epidemiological sceneries varied among countries, according to the adopted mitigation measures and epidemic phase. Recently, a recrudescence of the epidemics has been observed in distinct countries. SARSCoV- 2 can be transmitted by direct or indirect contact. The viral RNA has been detected in stool and other clinical specimens from infected patients and a putative fecal-oral transmission has been argued. Viruses are shed in human excreta, further disposed into the sewerage system or into the environment, in poor sanitation settings. Thus, SARS-CoV-2 RNA has been regularly detected in wastewater and surface water impacted by the direct discharge of sewage. Some studies ha
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Biomedical Science and Research Journals | Non-Invasive Low PEEP Versus High PEEP Ventilation Strategy in Severe COVID-19 Patients: An Observational Case – Control Study

  Non-Invasive Low PEEP Versus High PEEP Ventilation Strategy in Severe COVID-19 Patients: An Observational Case – Control Study Abstract Since the best ventilation strategy of severe covid-19 patients is still uncertain, we conducted a retrospective case–control study to evaluate the outcome of severe covid-19 patients treated in the emergency department (ED) with a non-invasive low positive end-expiratory pressure (PEEP) and early weaning strategy and compared it to a non-invasive high-PEEP strategy. Primary outcome was a composite outcome of ETI rate and/or in-hospital mortality at 7 and 28 days from admission to the ED. We compared 24 severe covid-19 patients treated with non-invasive low-PEEP to 26 sex- and age-matched controls. Main demographic characteristics, p/F ratio, creatinine, procalcitonine, C-reactive protein, d-dimer levels, APACHE II score and NEWS were comparable at admission. The case group received more frequently antivirals (mainly darunavir/cobicistat) and hydroxy
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