BiomedGrid

  Cerebral Tuberculoma without Clinical Pulmonary Tuberculosis Mimicry as Cerebral Abscess: (A Rare Case Report) Abstract Cerebral tuberculoma is approximately 10-15% of intracranial tuberculosis cases and 1% of all Mycobacterium tuberculosis (MTB) cases. Mostly, Cerebral tuberculoma is always accompanied by pulmonary tuberculosis infection. However, clinical and radiological symptoms of cerebral tuberculoma has mimicry with other brain infections. Gold standard of cerebral tuberculoma is histopathological finding, but it isn’t hard to do so MRI and MRI spectroscopy are used to make sure this diagnosis. In this case we will explore cerebral tuberculoma without clinical pulmonary tuberculosis has mimicry cerebral abses Case Presentation:  20-years-old woman, complained a progressive left side body weakness accompanied by an intermittent headache for 6 months ago. She had also complained a discharge appeared from both ears for 7 months ago. Patient’s contact history of tuberculo...

Calcium Dysregulation and Mitochondrial Dysfunction Form A Vicious Cycle in Parkinson’s Disease Abstract Mitochondria are not only the “power houses of the cell” but also function as a major Ca2+ buffer in the cell. Mitochondrial dynamics respond to the level of Ca2+ in the cell in order to maintain a beneficial feedback cycle between Ca2+ buffering and mitochondrial dynamics that allows adaption of mitochondrial to the cellular (sub) environment. Mutations in proteins linked to Parkinson’s disease (PD) as well as are linked to both mitochondrial dysfunction and Ca2+ dysregulation, which can trap the cell in a vicious cycle. The high energetic demands and high Ca2+ of dopaminergic neurons may explain why this cell type is the most vulnerable to mutations in PD related genes. Introduction Neurons depend on a healthy pool of mitochondria, as they require large amounts of energy and Ca2+ buffering, yet their highly extended, complex structures and long axons [ 1 ] make maintaining and dis...

  The Use of Ambrosia Moritima Methanolic Extract as Nephroprotective against Rifampin Induced Nephrotoxicity in Rats Abstract Background and Objectives: Nephrotoxicity is a progressive loss in kidney function over a period of months or years. Rifampicin (RIF) is the first line drug for the treatment of tuberculosis and can cause nephrotoxicity in human beings and animals. Material and methods: Nephroprotective effect of methanolic extract of, Ambrosia moritima leaves was studied in healthy albino rats (1.25-1.75 kg) of either sex. This plant is a flowering plant in the family Asteraceae, they are distributed in the tropical and subtropical regions. It is used in traditional medicine for the treatment of renal failure, inflammation of kidney and other diseases. The renal toxicity was produced by administration of rifampin at dose rate of 70 mg/kg I/p for 28 days. The plant extract was given by simultaneous oral administration of methanolic extract of Ambrosia moritima leaves at a d...

  Status of Water Used for Drinking and Irrigation in Kano: A Critical Review on Physicochemical and Heavy Metals Concentration Abstract Water is one of the most important natural sources for the sustenance of all living organisms. The importance of water to human’s ranges from domestic, industrial and also irrigational activities. The quality of water is affected by human activities as a result of urbanization, population growth, industrial production, climate change and other factors. Several attempts have been made by researchers in order to ascertain the sources of pollution of water in Kano state. This review provides a clear picture of various water analysis carried out by some researchers from different locations in the state. The water status of rivers, dams, ground water and sachet water used in Kano were presented in this paper. Based on the data considered in this paper, revealed that parameters in sachets and ground water consumed in Kano are within the WHO recommended ...