BiomedGrid

  Man: The Profound Change Mini Review A statement: A profound change knocks at the door! People’s reaction - condescending smiles and shout: We’ve all seen it, we all know it! But it is not true. A profound change is in fact at our door, if it has not already begun to enter the house and the spirit, but few have seen it and still less have perceived it. In any case, resistances to change are expected, which in a succinct way, we will say whether they are consciously assumed or not, can be due to: a) the natural fear of innovation and everything that is new. b) to the installed interests and the fear of losing stewardship. c) the incommensurability between paradigms that Kuhn had already talked about. Sport: A Tool and an Instrument Sport is a structuring phenomenon in any society nowadays. With great weight in the lives of individuals and societies, just see the space that it occupies in the media and in the conversations and debates between people, sport has gained a dimension th...

  Physiological Strength and Body Reaction after Training at the Male 2500m Oxygen Deprivation Chamber Abstract This study was to verify the influence of environment assumed elevation (FiO = 15.72% with the altitude 2500m) intermittently to change certain physiological functions, biochemical and body composition of male sprinters in this study. Twelve males were randomly divided into 2 groups, a hypoxia (H) group 2500m (n = 6, age: 20 ± 1.789 years, body height: 171.833 ± 5.672 cm, body mass: 62.7 ± 4.545 kg) and a control (C) group (n = 6, age: 21 ± 2.881 years, body height 178.0 ± 3.688 cm, body mass: 68.017 ± 4.5 kg). After the training program the results showed that both groups had significant changes (p <0.05), but the analysis showed that group (H) in the training in hypoxia caused changes significant (p <0.05), better than group (C) (HRmin reduce -9.17bpm, vital capacity (VC) to 0.42 liters, increase in 3000m run (0.94%), VO2max (3.98%), hemoglobin (1.3%), hematocrit ...

  Harmonizing Core Platforms In The Delivery of Patient-Specific Cell Therapies To Accelerate Patient Access To Life-Changing Treatments Introduction As our knowledge of human biology has grown, the newly found information has been leveraged to devise increasingly complicated treatments. This began with small molecule treatments that impact cell functions and has led to the rapidly maturing biologics space that largely aims to upregulate and downregulate those functions. This, in turn, has led to the emerging field of cell and gene therapy, where the aim is to create, renew, or replace cell functions and directly affect human tissue. Significant excitement has led this field to evaluate its’ benefits in a breadth of disease areas with leading candidates in oncology and congenital blood diseases. However, along with this anticipation comes questions about how the pharmaceutical industry will support these complicated and, therefore, expensive treatments to ensure patients are able t...

  He4 Marker in Endometrial Cancer: Reality or Fiction? Abstract Purpose of the review:  HE4 has been recently studied in endometrial cancer, but no conclusive results have been obtained. The role of the marker to differentiate between benign pathology and cancer and its relationship with factors of poor prognosis in endometrial cancer has been studied in this review. Conclusions:  Clinicians could use HE4 marker in women with endometrial cancer to help them in the preoperative decision-making process. Keywords:  Endometrial Neoplasms; HE4; tumor marker Introduction Endometrial cancer (EC) is the sixth cause of cancer in women in developed countries and the 2% of cancer deaths in woman [ 1 ]. Most cases of EC have good prognosis as they are usually diagnosed in early FIGO stage (80% in stage I). The survival rate in 5 years is about 80-85% [ 2 ] which decrease if metastasis or regional spreading appear (5 years survival of 68 and 17 % respectively) [ 3 , 4 ]. The mos...

  Avoiding Malthus 2.0: Why Food Pessimism Leads Nowhere Opinion Planet Earth’s natural resources, such as land, freshwater, raw materials etc., have to be shared among an increasing number of people (and farm animals). Moreover, human life expectancy has continuously increased. Consequently, more people consume for longer, leading to fears whether there is enough for all of them, now and in particular in the future. One particular concern is about human diets and their resource implications. Globally, agriculture accounts already for up to 40% of global land use and 70% of freshwater withdrawals [ 1 ]. Moreover, food systems contribute 19-29% of global anthropogenic greenhouse gas (GHG) emissions of which agricultural production, including indirect emissions resulting from land-cover change, contributes 80-86% of total food system emissions [ 2 ]. In 2013, food represents 97% of world agricultural production (value) and 23% of world food production was exported, according to FAOST...