BiomedGrid

  The spectrum of Thyroid function Abnormalities and associated Biochemical factors in Patients with Chronic Kidney Disease in Cameroon Abstract Background:  Chronic Kidney Disease (CKD) can lead to thyroid function disorders. The extent to which this relationship exists among Cameroonian CKD patients is not known. The aim of this study, was to determine the spectrum of thyroid dysfunction (TD) and their associated factors among CKD patients in Cameroon. Methods:  A cross-sectional study was conducted over a period of 12 months (July 2018 to August 2019) in three referral hospitals (Douala General Hospital, Laquintinie Hospital, Bafoussam Regional Hospital) in Cameroon with patients aged 18years and above diagnosed of CKD stage 1 to 5. Patients with stage 5 dialysis and those on thyroid altering medication were excluded. For each participant, we collected socio-demographic and clinical data. Sera were used to determine thyroid hormone profile, lipid profile, liver test, u...

  Covid-19 (SARS-CoV-2) VS Sars-CoV; Summary of all things that healthcare providers should know Abstract The corona viruses are members of a family of enveloped viruses that replicate in the cytoplasm of animal host cells. They are distinguished by the presence of a single-stranded plus-sense RNA genome about 30 kb in length that has a 5′ cap structure and 3′ polyadenylation tract. Upon infection of an appropriate host cell, the 5′-most open reading frame (ORF) of the viral genome is translated into a large polyprotein that is cleaved by viralencoded proteases to release several nonstructural proteins, including an RNA-dependent RNA polymerase (Rep) and an adenosine triphosphatase (ATPase) helicase (Hel). These proteins, in turn, are responsible for replicating the viral genome as well as generating nested transcripts that are used in the synthesis of the viral proteins. The mechanism by which these subgenomic mRNAs are made is not fully understood. The SARS-CoV genomes are about ...

  Bing Neel Syndrome: Real Life Data and A Review of the Literature Abstract Bing-Neel syndrome is a rare complication of Waldenström’s macroglobulinemia defined by the infiltration of malignant lymphoplasmacytic cells into the central nervous system. We present the results of a retrospective study aimed at describing real life data of 12 patients with Bing-Neel syndrome. Our findings are compared with data in the literature. Our study provides additional insights on the characteristics and outcomes of patients with the Bing-Neel syndrome. Keywords:  Bing Neel Syndrome; Waldenström’s Macroglobulinemia; Central Nervous System Abbreviations:  BNS: Bing-Neel Syndrome; CNS: Central Nervous System; CSF: Cerebrospinal Fluid; MRI: Magnetic Resonance Imaging; 18F-FDG PET: 18Fluor-Fluordeoxyglucose Positron Emission Tomography; LPL: Lymphoplasmacytic Lymphoma; MGUS: Monoclonal Gammopathy of Undetermined Significance; WM: Waldenström’s Macroglobulinemia Introduction Waldenström’s m...