BiomedGrid

  Current and Future Challenges In Drug Therapeutics for Sars-Cov-2 Infection in Covid-19 Pandemic Abstract Keywords:  Pandemic, COVID-19, SARS-CoV-2, Therapeutics, Vaccines, Antivirals Introduction Pneumonia of unknown cause detected in Wuhan; China was first reported to the WHO Country Office in China on December 31 2019. Later, the causative agent of which was identified to be Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). On March 11, 2020, the pandemic caused by the SARS-CoV-2 was termed as COVID-19 by the World Health Organization (WHO), with the disease touching practically every country in the world. The SARS-CoV-2 infection is, although characterized by flu-like symptoms, the fast progression is attributed to the acute respiratory distress syndrome (ARDS) [1] or myocarditis [2]. Many other manifestations of the disease have been described in different patient groups across different countries. As of May 11, 2020, the total infections globally stand at 4...

  The Colloid Vibration Potential Effect from Silica Suspensions Using Electroacoustic Spectroscopy Abstract Electroacoustic techniques are vital tools in order to characterize colloidal suspensions. When an acoustic wave is applied to a source of colloidal suspension, a vibration potential is generated as a result of the interaction. This particular responded potential is termed Colloid Vibration Potential (CVP) and is detected as an AC electrical signal. We address the physicochemical properties upon measuring the CVP for Silica Dioxide (SiO2) colloidal particles with three different concentrations of 0.5, 1 and 5% by wt., and a Particle Size Distribution (PSD) ranging from 35, 70, 100, 165 and 190nm. Our experimental technique has relatively eased access to the colloidal source and in addition provides an improved signal to noise ratio with implementation of a fully external detector to sense the generated responded signal. Current study provides relatively consistent measuremen...

  Antibiotic Resistance Genes: Boon or Bane? Abstract Keywords:  ARG’s; HGT; DNA Transformation; Environmental Contaminants; GMO’s Abbreviations:  ARG’s: Antibiotic Resistant Genes; HGT: Horizontal Gene Transfer; GMO: Genetically Modified Organism Introduction Bacteria are very dynamic organisms in nature and possesses exclusive ability to uptake foreign DNA and replicate them. This unique ability works in their favor to survive environmental changes and evolution. For instance, bacteria can uptake DNA that makes human insulin which can be useful to treat type I Diabetes. This very reason makes bacteria the most popular organism, that is widely used in research for amplifying desired gene and the process is called bacterial transformation. Bacterial transformation was first reported in 1928 by Griffith [1] in Streptococcus pneumoniae where some bacteria take up foreign genetic material from environment by horizontal gene transfer (HGT). In research labs the bacterial DNA ...

  Investigation into the Cytoprotective Potential of Ethanol Extract of  DenettiaTripetalain  Wistar Rat Abstract Pepper fruit (Dennettia tripetala) is well known for its wide range of medicinal values which include bowel cleansing, facilitation of digestion and absorption of cholesterol, anti-cancerous effect, anti-microbial effect among many others. But not much has been reported on its cytoprotective effect on the gastric mucosa in spite its widespread use. The current study therefore focuses on evaluating the cytoprotective effect of the extract in wistar rats. Fifteen (15) rats weighing 160-180g were randomly assigned into three groups of five rats each. Group 1 (control), group 2 (low dose group) and group 3(high dose group). Group 1 received 0.5ml of normal saline while Groups 2 and group 3 (experimental groups) received respective doses of 0.00085ml/g body weight and 0.0017ml/g body weight of the extract. The administration was twice a day and lasted for 28 days. ...