BiomedGrid

  A Stepwise Infection and Immunity Strategies to Prevent and Treat an Emerging Infection Abstract Global warming, transportation and urbanization expose humans to novel pathogens for emerging infections arising from microbial mutation, vector-borne and/or zoonotic transmission. We have experienced and studied immunopathogenesis of 4 emerging infections including enterovirus 71 encephalitis, dengue hemorrhagic fever, severe acute respiratory syndrome (SARS), and novel influenza A(H1N1) in the past 2 decades. Based on our studies and references from literature, here, we have summarized a stepwise infection and immunity regimens to prevent and treat an emerging infection. A consensus to monitor virus-host-environment interactions in the global village is the most important thing, particularly the potential mutants of emerging RNA viruses and herd immunity of risk populations, poultries, vectors and wild animals. In this article, we provide a stepwise infection and immunity strategies...

  Why the Biomedical Research Paradigm Must Change if we are to Win the “War on Cancer” Abstract Objectives:  The purpose of this article is to begin a dialogue concerning the consequences for research design and data interpretation of outdated assumptions underpinning current biomedical research. Methods:  Integrated analysis and review of the ways in which the exclusion of physics (quantum theory) and biophysics data (endogenous bioelectric signaling) in biomedicine have biased research design and data interpretation. Concrete consequences for clinical oncology research are used as illustrations. Results:  Accumulating data demonstrate that biomedicine is about 100 years out of date with respect to its understanding of physics. This has led to detrimental consequences for clinical oncology. Conclusions:  Evidence based medicine is only as good as the completeness and veracity of the data that support it. Widespread emphasis on particulate aspects of wave/parti...

  Scenario of Chronic Hydroarsenicism in Arid Zones and Toxic Risk in Goats Opinion There is really a strong environmental problem with hydroarsenicism in different countries of the world, mainly in Asia and Latin America; there are reports of chronic poisoning from exposure to high concentrations of arsenic in Bangladesh, India, Taiwan, Thailand, China, Hungary, Serbia, United States, Chile, Brazil, Argentina and Mexico [1]. In 1993 the World Health Organization (WHO) set 10μg L-1 as the guideline value for arsenic in drinking water [2]. However, the maximum allowable limits for animal consumption are not yet well established, and therefore different reference values have been considered, including 25 and 200μg L-1 [3,4]. In many parts of the world, both the problem of arsenic in groundwater and goat farming coincide in arid zones, together with agriculture and cattle breeding activities. These activities require large volumes of water for their performance and generate an increas...

  COVID-19 hospital admission appropriateness analysis Introduction Inconsistencies in clinical practice, coupled with uncertainty, are constants across all scenarios and throughout all time. In countries with better-developed healthcare models, overuse is far more problematic than underuse, hence the appearance of methods for assessing hospital inadequacy at the end of the 20th century [1]. During the COVID-19 pandemic, hospital admission criteria have been questioned based on the alleged inconsistency between hospitals [2,3]. Several studies put the proportion of inappropriate visits to hospital emergency services at between 20% and 80% of the total [4,5]. However, these studies date to the pre-SARS-CoV-2 pandemic period. Purpose This study was to compare hospital admission criteria applied to COVID-19 patients in the emergency department of the Ramón y Cajal University Hospital (HURyC) and their alignment with the AEP (Appropriateness Evaluation Protocol) and PSI (Pneumonia Seve...

  Safety and Precautionary Measures for Staff and Students During the Covid 19 Pandemic: A Malawian College of Health Sciences Case Introduction The coronavirus (Covid-19) pandemic is exacting a huge toll on individuals, families, communities and societies across the world [1]. Furthermore, the pandemic has changed the lives of individuals, families, communities and societies globally (Inter-Agency Standing Committee; 2020). The protection of students, staff and educational facilities is particularly important during Covid-19 pandemic [2]. According to the Centre for Health protection [3], schools/ colleges need to develop precautionary measures to minimize the risk of contracting and spreading Covid-19 after class resumption. Safety measures taken by schools/colleges can prevent the entry and spread of Covid 19 by students and staff who may have been exposed to the virus [1]. As of 24th March 2020, confirmed global COVID 19 incidences were 39827, with a reported death toll of 1722...

  Osteoarthritis of the Knee: Recent Advances and Management During COVID-19 Era Abstract Osteoarthritis is a debilitating joint disorder that causes progressive weakening of the articular cartilage and the synovium leading to a stiff joint. It is a very common inflammatory disorder that has been closely related to aging, obesity, genetics, mechanical stress, medications, and injury. Osteoarthritis has a multifactorial etiology including constitutional and mechanical factors, biochemical processes, cellular processes, mechanical forces, local inflammation, genetic predisposition, and joint integrity. Older and newer therapies are continuously under investigation, and some have shown promising preliminary results in many studies. This review aims to give an overview of the current knowledge of therapies available for knee osteoarthritis with a focus on non-surgical intervention, especially in the COVID-19 era. COVID-19 has imposed a challenge to the usage of traditional methods and ...