BiomedGrid

Features of Reduction of Th1, Th5 Lymphocytes Functions After Intoxication of Various Toxic Chemicals Abstract Experiments on random-bred albino rats showed that organophosphorus compound (malathion) acute intoxication (0.5 LD50) in the greater degree reduces function of Th1 lymphocytes and bound with them of delayed-type hypersensitivity (DTH) reaction and production IFNγ, in comparison with function of Th5 lymphocytes and synthesis of IL-4 by them; the opposite effect is characteristic for methanol (0.5 LD50; decreases Th5-lymphocytes function (IgG and IL-4 production) to a greater extent); acetonitrile and trichloromethane acute intoxications (0.5 LD50) invokes a reduction of functions of Th1 and Th5 lymphocytes and production of cytokines by them (IFNγ and IL-4) equally. Keywords: Toxic Chemical; Immunotoxity; Th1, Th5 Lymphocytes; Cytokines Introduction Depression, Anxiety, Stress and Fear Toxic chemicals (TCh) may have a differe...

Endothelial Progenitor Cells: Characterization and Role in Cerebral Arteriovenous Malformation Abstract Background: The angiogenesis in Cerebral Arteriovenous malformations (cAVMs) may occur through activation of chemokines [stromal-cell derived factor-1 (SDF-1)], which ultimately recruit endothelial progenitor cells (EPCs) for aberrant neovascularization. Thus, we determined the role of EPCs in the vasculogenesis of cAVMs. Methods: Literature search was made through electronic database on “PubMed”, “EMBASE”, “Google Scholar”, and “Science Direct” from 1990- 2019 using MeSH headings of “Endothelial Progenitor Cells”, “Arteriovenous Malformation”, and “Stromal-cell derived factor-1 (SDF-1)” using Boolean operator “and”/”or”. The inclusion criterion included human experimental studies on EPCs in the cAVMs. Results: Histo morphological characteristics of vasculogenesis, both quantitatively and qualitatively, are pivotal in determining the prognosis of pat...