BiomedGrid

  To Develop an App or Technology Platform for Interprofessional Education & Collaboration for Research Outside Universities & Create Partnerships with Organizations to Create New Learning and Career Opportunities for Dental Hygienists Opinion The oral-systemic link and pathogenesis of inflammation are the key drivers for the body's diseases. Dental hygienists are one of the most underutilized professions in healthcare today. Dental hygienists have a broad base of education with medical and dental knowledge that will be the key conduit to provide preventative healthcare. Dental hygienists must take continuing education courses in several medical and health topics to maintain their licenses every two to three years depending on the state they live in. Some of the educational courses consists of medical emergencies, aseptic techniques, pharmacology, anesthesia, cardiopulmonary respiration, diabetes, oral pathology, and many others. In the future, the American Dental Hygiene A...

  Health Related Quality of Life Perceived Among Caregivers and Breast Cancer Patients in Pakistan: Time to Ponder Abstract Introduction:  Breast cancer has been considered as an emerging non-communicable threat in Pakistan. Limited access to health care facilities, a smaller number of qualified oncologists, lack of technical equipment for diagnosis are the major factors effecting adequate control and prevention of breast cancer in Pakistan. Objective:  The present study was designed to assess health related quality of life among patients of breast cancer in Pakistan. Methodology:  A descriptive cross sectional study design was used to assess health related quality of life among 382 breast cancer patients and 71 care givers using EORTC QLQ C 30. Data was collected and statistically analyzed. Results:  Out of 453 respondents 84.3%, (n=382) were patients while 15.7%, (n=71) were care givers. Out of all the patients, 11.3% (n=43) had stage 1 of breast cancer and 70...

  droTAG: Adapting dTAG Toolkit to Drosophila Melanogaster Opinion Targeted protein degradation (TPD) allows an acute and reversible knockdown of protein of interest (POI) so that the direct effects of protein depletion can be studied and distinguished from secondary effects or adaptive responses [1]. Therefore, protein degradation techniques apply in studying the function of gene products in a short time frame, and rapid effectiveness can be exploited to downregulate POI in a stage-specific manner or when time is a relevant factor, including cell division. In the last decade, several strategies have been developed to obtain an accurate and efficient protein degradation, such as deGradFP, Auxin-inducible Degradation (AID) and degradation TAG (dTAG) which aim to achieve proteolysis of POI exploiting the powerful of degradation signal peptide sequences (tags) to hijack POI to E3 ubiquitin ligases for ubiquitylation and consequentially proteasomal degradation by recruitment of the ubi...

  The Potential Detrimental Effects on Multiple Organ Systems in COVID-19 Patients Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes COVID-19, which spreads between people, mainly when an infected person stays in close contact with another one. The infection starts off with mild flu-like symptoms to severe in the several aspects. In the most cases, COVID-19 patients usually develop mild to moderate illness and recover at home stay with nominal medications. The usual signs of COVID-19 are fever, dry cough, loss of taste, tiredness etc., in very rare cases symptoms are difficulty in breathing, muscle pain, chest pain, loss of speech or movement etc. The deceased people from COVID-19 reveal the expected features of severe pneumonia or acute respiratory distress syndrome (ARDS). The virus seems to directly cause inflammation in the small capillaries or blood vessels leading to blood clots and damage heart, liver, brain and kidneys. In some people, it can affe...

  The Progesterone-Oocyte Index as a Predictor of the Final Outcome of an IVF Cycle Abstract Aim:  To compare the serum levels of progesterone (P) on the day of human chorionic gonadotropin (hCG) administration and the progesterone-oocyte index (POI) on the day of follicular puncture, in relation to the clinical pregnancy rate obtained in cycles of in vitro fertilization (IVF). Material and method:  Between March 2011 and December 2014, a retrospective observational study was performed at a third-level hospital, during which 1691 IVF cycles were analysed. A new variable, the progesterone-oocyte index (POI), is calculated for each cycle included in the study by dividing the serum P level (ng/ml) on the day of hCG administration by the total number of oocytes obtained by follicular puncture, and the pregnancy-prediction accuracy of the serum P level on the day of hCG administration was compared with that of the POI. Results:  The adjusted odds ratio for the probability...