Biomedical Science & Research Journals | Individual Approach to Hormone Replacement Therapy – A Computer Assisted Method of Assessment of the Minimal Useful Dose

Estrogen replacement therapy (ERT) was primarily used to treat vasomotor symptoms, it had been increasingly viewed as a way to prevent chronic diseases of aging, including coronary heart disease (CHD), cognitive impairment and osteoporosis [1-3]. Osteoporosis leads to bone fractures. Death rate due to osteoporosis is higher than the mortality rate attributed to breast and endometrial cancer combined. Estrogens are considered the gold standard in assessing the efficacy of various medications in osteoporosis treatment [1,2]. At least 40% of postmenopausal women in the United States were using ERT before the publication of the Women’s Health Initiative (WHI) report, which addressed the risks and benefits of ERT [1,4]. WHI trials addressed the most commonly used hormone formulations at the time in the United States -- conjugated equine estrogen (CEE) plus medroxyprogesterone acetate (MPA). Findings from these trials have been extensively published during the past decades [5-7].

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