Biomedical Science & Research Journals | Sterile Root Canal: Obturation is Not Sterilization

In normal healthy metabolism we do not have inflammation due to micro-organisms, since Inflammation is an adaptive process to the noxious stimuli that the human body is constantly exposed to. From the local inflammatory response to a full-blown systemic inflammation, a wide complex sequence of events occurs Persistent immunosuppression and catabolism may ensue, until multiple organ failure finally sets in... A thorough understanding of these events (how they begin, how they evolve, and how to modulate them) is imperative, but yet poorly studied. 



 

Comments

Post a Comment

Popular posts from this blog

AJBSR FAQs: Key Answers to Biomedical Research and Publishing Questions

 AJBSR FAQs: Key Answers to Biomedical Research and Publishing Questions Q: What are the Manuscript Guidelines in Open Access AJBSR? A: The Manuscript Guidelines for the American Journal of Biomedical Science & Research (AJBSR) provide detailed instructions for authors preparing their submissions. The manuscript should be structured as follows: a Title Page including the manuscript title, authors' names, affiliations, and contact information for the corresponding author; an Abstract summarizing the research in 150-300 words with key findings; 3-6 Keywords reflecting the main topics; an Introduction outlining the background, reasons, and objectives; Materials and Methods detailing the study design and procedures for replication; Results presenting findings with appropriate tables and figures; a Discussion interpreting the results and their significance; a Conclusion summarizing main findings and implications; Acknowledgments for contributors, funding sources, or institutions; ...
Read more

Biomedical Science and Research Journals | On Random Center Grouping in Multicenter Clinical Trials

Image
  On Random Center Grouping in Multicenter Clinical Trials Abstract With the attention of achieving desired power within a pre-specified timeframe in clinical development, a multicenter trial is often conducted to expedite the patient recruitment. However, a multicenter trial with plethoric number of centers is very likely to result in numerous small centers, which will cause the problem of treatment imbalance (unequal number of patients per arm within a center) and/or center imbalance (a few large centers with a number of small centers). In practice, treatment imbalance within and between centers inevitably occurs regardless the randomization models and/or methods used. Treatment imbalance within center and/or center imbalance will not only (i) increase the probability of observing treatment-by-center interaction, but also (ii) decrease the power for detecting clinically meaningful difference (or treatment effect) of the test treatment under investigation. In this paper, we propos...
Read more