Biomedical Science and Research Journals | Quantum Chemical and Pharmacokinetic Studies of some Proton Pump Inhibitor Drugs

Proton-pump inhibitor (PPIs) drugs are widely used in the treatment of gastric diseases. Almost all PPI drugs have some side effects depend on the physical condition and limit of doses. In this study, the physicochemical and pharmacokinetic studies of Omeprazole, Esomeprazole, Lansoprazole and Pantoprazole have been investigated. Density functional theory (DFT) with B3LYP/3-21g basis set has been employed to optimize the geometry and to elucidate their thermochemical, molecular orbital, molecular electrostatic potential properties. Pharmacokinetic parameters are also investigated to compare their absorption, distribution, excretion, metabolism, and toxicity. Omeprazole, lansoprazole, pantoprazole and esomeprazole having the benzimidazole nucleus and widely used in gastrointestinal treatment [1]. They play a significant role as proton pump inhibitors (PPIs) [2]. 
PPIs are not only very effective but also safer agents applied for the treatment of various gastrointestinal disorders, where they restrict the gastric acid production [3]. They deliver the best medication for gastroesophageal reflux disease (GERD) and erosive esophagitis through gastric acid suppressive therapy. Besides these drugs also used as a remedy of a helicobacter pylori infections. Generally, stomach acids are highly responsible for digesting nutrients whereas decreasing these acids can provide relief from heartburn and indigestion. Most importantly these drugs (Omeprazole, lansoprazole, pantoprazole and esomeprazole) are differ from each other in their metabolism and as well as in efficiency to interact with other prescripts. From more than a decade these drugs have been widely used as an acid inhibitory agent for treatment related to gastric acid secretion [4]. They irreversibly restrict the enzyme scheme by blocking the H+/K+ ATPase system [5]. Headaches, diarrhea, abdominal pain, vomiting etc. are the common side effects where long term use may rise the risk of gastric cancer and bone fracture as well.


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