Biomedical Science and Research Journals |Acute Pneumonia Today: The Worship of Antibiotics and The Neglect of Biological Laws
The results of studies and clinical trials of pathogenetic approaches in
the treatment of acute pneumonia (AP) were obtained in the period
from 1976 to 1985 on the experience of treatment and monitoring of 994
patients. Over the past period, there has been a steady decline in the
effectiveness of antibiotic therapy, an increase in the number of
complications in AP with frequent development of dramatic situations,
the lack
of expected changes after the start of vaccination, the deficit of
strategic plans to solve the problem. All these reasons only increase
the relevance
and timeliness of the proposed materials. The main attention is paid to
biological stereotypes of dynamics of acute inflammatory processes of
nonspecific etiology. Underlying the inflammatory transformation of
tissues vascular reactions determine the fundamental difference between
the
pathogenesis and clinic AP from other lesions of this nature, as this
disease is the only one in this series, which is localized in the small
circle of blood
circulation. The proposed principles of pathogenetic treatment are based
on new ideas about the nature of AP and the unique mechanisms of its
pathogenesis. The results obtained give confidence in the possibility of
guaranteed prevention of complications of the disease
Acute pneumonia (AP) for a long period of its fame has
always been considered an inflammatory disease of nonspecific
etiology. Such cardinal feature of infectious diseases as contagion
never appeared in descriptions of AP as this characteristic had
no actual confirmation. The mental perception and importance
of microbial factor in AP began to change after the discovery and
use of antibiotics. Moreover, such a transformation of views on
the nature of AP has a paradoxical feature: as the effectiveness of
antibiotics decreases, all treatment failures are explained only by
the peculiarities of the microflora. Therefore, AP as a nosological
form has not changed its cardinal features, but in recent years
it is increasingly represented and interpreted as an infection.
This “infectious bias” in terminology and classification would be
logical and justified if there were real evidence, such as contact
transmission and epidemics. However, the idea of the nature of AP
as an infectious disease is nothing more than a consequence of a
long therapeutic fascination with antibiotics, which continue to be
considered a universal remedy and panacea.
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