BiomedGrid

  Hepatic Adenomas Challenges to their Diagnosis and Management with Emphasis on the Bordeaux Classification Goals and Learning Objectives a. To discuss the etiology and natural history of HA. b. To detail the importance of the Bordeaux Classification. c. To provide a comprehensive approach to their correct identification based on imaging and pathological features. d. To present the risk factors associate with hepatic carcinogenesis. e. To elaborate on the entity of hepatic adenomatosis. f. To detail on the state-of-the-art management of HA and adenomatosis. g. To emphasize their association to congenital cardiac conditions and other syndromes. Disclosure Statement Authors have nothing to disclose. Etiology and Natural History of Hepatic Adenomas (Ha) It has been postulated that disrupted hepatic vasculature results in the development of hepatic lesions including hepatic adenomas, FNH, and hemangiomas. The etiology of HA is that an altered hepatic circulation stimulates the evoluti...

  Sedation and Twilight Anesthesia Induced by  Ascofregata Purin  Song Abstract Twilight sedation as an alternative to general anesthesia is used when the latter is unnecessary or contraindicated, or when the patient needs to remain responsive to requests from the medical practitioner. Here we report on an ethnomedical case, in which animal vocalizations traditionally used as lullabies were tested for their ability to induce varying states of sedation up to anesthesia and found to effectively induce anesthesia approaching twilight sedation. Introduction Twilight sedation suppresses the central nervous system to enable surgical procedures for which general anesthesia is not necessary or permissible [ 1 ]. The drugs used in twilight sedation are not without risk. Compounds such as nitrous oxide, ketamine, propofol, milotic, midazolam, benzodiazepine, marowak, sentret, and fentanyl have known undesirable effects, even when used correctly [ 2 ,  3 ,  4 ,  5 ,...

  Epidemiology of Creutzfeldt-Jakob Disease in Floridian Men and Women: 1988-2012 Abstract Creutzfeldt-Jakob disease (CJD) is a rare and fatal prion brain disorder with unknown etiology. In the current study, we characterized the epidemiology of CJD in the population of Florida. Cases of CJD were identified using the principal diagnoses by ICD-9 code among 55 million inpatient hospital discharge records reported to the Florida Center for Health Information and Transparency from 1988 to 2012. We examined basic demographic and clinical characteristics, and trends in the annual incidence for men and women. We identified 390 patients with CJD. Most patients were Caucasian (90.0%) and 51.3% were male. The median age of hospitalization was 67 years (Interquartile range: 14). The overall annual incidence was 0.91 per million (95% Confidence Interval: 0.8-1.0) and the overall rate was slightly higher for men than women (0.94 versus 0.87 per million, respectively). Annual rates were similar...

  The Implication of Hypoxia and Cancer Stem Cells on Tumor Vasculogenesis Abstract Tumors vasculature and lymphogensis are crucial for growth and metastasis. Tumor vessels are characterized by irregular structure with higher permeability than normal vessels. This irregularity in shape results in micro-regional hypoxia due to inadequate oxygen supply to tumor cells. Triggered by hypoxia and mediated by Cancer Stem Cells (CSCs), both angiogenesis and Vasculogenic Mimicry (VM) were found in many solid tumors including breast cancer, melanoma, Head and Neck Squamous Cell Carcinoma (HNSCC). Tumor Angiogenesis and Cancer Stem Cells (CSCs) Tumor angiogenesis develops due to injury in the basement membrane in tissue and creation of hypoxia thus releasing angiogenic factors that activate endothelial cells to migrate, proliferate and stabilize[ 1 ]. The activation of the angiogenic factors such as Vascular Endothelial Growth Factor (VEGF), Basic Fibroblast Growth Factor (bFGF) and angiogeni...