BiomedGrid

  Molecular Characterization of Multi Drug Resistance  Escherichia coli  isolated among Diabetes Mellitus Patients in Dongla State, Sudan Abstract Background: Urinary tract infections (UTIs) caused by Escherichia coli have become a significant worldwide public health concern and is a common infectious disease in which level of antimicrobial resistance are alarming worldwide. Methods: Urine samples were collected form Diabetic patients clinically diagnosed by having UTI, during the period from November 2019 to April 2020 at diabetic center in Dongla, Antibiotic susceptibility tests were performed by Kirby-Bauer disc diffusion and B-lactamases genes were detected used PCR. Results: A total of 120 E. coli were Isolated from DM with UTI. All the isolated were shown to be resistant to Cefpodoxime (100%). The most efficient antibiotics were Colistin and imipenem (99.2% and 88.3 respectively as susceptibility rate) followed by Gentamycin (70%). High resistance rates were observe...

  Modified Polypropylene Nonwoven Textile for Filter Facial Masks Introduction Coronavirus (COVID-19) the most frequently spreads from human-to-human through respiratory droplets. Due to the outbreak of the COVID-19 pandemic in 2020, the research of protective equipment, especially facial masks, increased significantly. The filtering materials of facial masks are typically nonwoven textile. These materials, initially using natural fibers, came into greater importance with the introduction of synthetic thermoplastics, particularly polypropylene (PP), which creates the basic material for nonwoven textile for facial masks production. PP is non-toxic, hydrophobic material, resistant to steam sterilization, with a good ability to be fiberized. Unfortunately, it is also relatively sensitive to microbial attacks, such as bacteria, viruses, and mould [1,2]. Therefore, a less microbially sensitive chlorinated polypropylene derivative (CPP) was electrospun and tested for production of nonwov...

  Fetal Cervical Teratomas: Etiology, diagnosis, and Treatment Options Introduction Cervical teratomas are rare fetal tumors with a frequency of 1 in 20,000 to 1 in 40,000 live births, with a female-to-male ratio of 3:1 [1]. In a series of 1,253 teratomas of different types [2,3], only 6 (0.47%) were classified as epignathus [4]. Histologically, they are benign tumours formed by the three germ layers (ectoderm, mesoderm and endoderm). While the majority of fetal teratomas manifest themselves in the coccyx region, cervical teratomas represent only about 6% of congenital teratomas. Moreover, there are some cases in the literature where cervical teratomas showed a malignant tendency. Thus Thurkow et al. [6] reported an extremely rare case of malignant teratoma of the neck, with mature and immature metastatic lesions in the lungs, in an immature fetus [5]. Further, Bauman and Nerlich reported a metastazing cervical teratoma of the fetus [6]. Additionally, there is another report of six...

  PCSK9 Deficiency Modulates Glucose Homeostasis and Insulin Secretion Via Pancreatic Ldl Receptors And Cholesterol Accumulation Abstract Intracellular lipid accumulation contributes to β-cell dysfunction in type 2 diabetes. How PCSK9 interacts with lipid metabolism to alter insulin availability/resistance is not well studied. Genetic deficiency of PCSK9 mice was fed a high fat (HFD; 45% Kcal from fat) for 14 weeks, and the metabolic phenotype including glucose, insulin, GTT, ITT, and cholesterol was examined. In addition, the expression of PCSK9 and LDLR was were examined by RT-qPCR, and immunohistochemistry. We provide data supporting a role for PCSK9 in pancreatic islets. In HFD mice, PCSK9 deletion led to impaired glucose tolerance and decreased insulin secretion. Pancreatic islets of HFD PCSK9-/ mice showed impaired insulin production and increased LDLR mRNA. Cholesterol was higher in islets of both HFD-fed WT and PCSK9 KO mice compared to low-fat diet controls. Glucose intole...

  Safety of Sofosbuvir and Daclatasvir in Patients having Ischemic Heart Disease for Treatment of HCV Compensated Cirrhosis Introduction Background:  Sofosbuvir is indicated for the treatment of chronic hepatitis C infection as a component of a combination antiviral treatment regimen. However, its safety in ischemic patients still needs more studies focusing on the inflammatory status that might worsen atherosclerosis. Objectives: to demonstrate the safety of HCV therapy in ischemic patients. Methods:  80 patients with history of ISHD received HCV therapeutic regimen, with assessment of cardiac biomarkers, ejection fraction, as well as carotid intima media thickness before and after the therapeutic protocol. Other laboratory test including CRP, RDW, serum creatinine, liver function test and lipid profile were done as well. Results:  No significant differences between cardiac biomarkers or the ejection fraction before and after the treatment course. Slight nonsignific...