BiomedGrid

Problem Solving and Finding Solutions for Children with Autism Spectrum Disorder: A Model Individuals with an Autism Spectrum Disorder (ASD) typically have higher support needs for life skills, social skills and mental health issues than most other populations and the amount of support needed likely will depend on the severity of the disorder and specific difficulties. In order to ensure high quality services for ASD individuals, a well-trained staff is essential for promoting life skills and decreasing mental health issues. The efficacy of essential personnel, as with all mental health issues, is hampered by the lack of formal and informal education and training, preparation and experience when working with ASD individuals. Not only is there a dearth of studies that present valid and reliable specific training for the treatment of ASD individuals, the few studies that do exist only offer modest information about effective strategies to intervene. Most do, however, indicate the nee...

A 42-year-old male with a history of chronic nephrolithiasis presented to the hospital after neighbors found him unconscious at home. On initial evaluation, he was febrile (38.9) with blood pressure of 120/104mmHg. He was severely hypoxic with a sinus rate of 90 beats/minute. His examination revealed multiple abrasions, and he was minimally responsive with a holosystolic murmur at the apex. His electrocardiogram showed normal sinus rhythm with no acute ST-T wave changes. Laboratory data revealed a white cell count of 17.4/nl, platelet count of 109/nl, lactate level of 4.8 mmol/l and creatinine of 1.57mg/dl. Computed tomography of the head revealed multiple regions of acute infarction involving the right inferior cerebellum, left occipital lobe with mass effect on the left occipital horn. He underwent a transthoracic echocardiogram that showed vegetations on both the mitral and aortic valve. He underwent a trans-esophageal echocardiogram, which demonstrated multiple vegetations on t...

The results of studies and clinical trials of pathogenetic approaches in the treatment of acute pneumonia (AP) were obtained in the period from 1976 to 1985 on the experience of treatment and monitoring of 994 patients. Over the past period, there has been a steady decline in the effectiveness of antibiotic therapy, an increase in the number of complications in AP with frequent development of dramatic situations, the lack of expected changes after the start of vaccination, the deficit of strategic plans to solve the problem. All these reasons only increase the relevance and timeliness of the proposed materials. The main attention is paid to biological stereotypes of dynamics of acute inflammatory processes of nonspecific etiology. Underlying the inflammatory transformation of tissues vascular reactions determine the fundamental difference between the pathogenesis and clinic AP from other lesions of this nature, as this disease is the only one in this series, which is loca...

Antiviral activities of Zn 2+ ions for viral pathogenesis process and inhibition by Zn 2+ ions for host cell-virus growth have been investigated. Zn 2+ ions inhibit viral entry, local replication, and spread to organ during viral pathogenesis process. ZFNs may become a potential antiviral agent for restricting HIV-1 integration. The ZAP inhibits viral entry and HIV-1 infection. ZMPSTE24 cooperates with IFITM to inhibit viral entry. ZNF502 was confirmed with siRNA knockdown of the host protein levels resulting in reduced RSV virus production in infected cells. Zinc finger-attacking compound can inhibit HIV-1 and MuLV zinc fingers viral replication in vivo, in which anti-retroviral drugs which target the nucleocapsid zinc finger may be clinically useful against HIV-1. Zn 2+ ions also inhibit Nidovirus replication that increasing the intracellular Zn 2+ concentration can efficiently impair the replication of a variety of RNA viruses. A viral infection spread in the infec...

Congenital malformations are estimated to be 2-4% of all births. Despite their relatively low prevalence, fetal malformations are responsible for approximately 30% of perinatal deaths, and considerable infant morbidity in developed countries [ 1 ]. Fetal malforml formations can be defined as structural or functional anomalies that occur during intrauterine life and can be identified prenatally, at birth or later in life. Congenital anomalies are also known as birth defects, congenital disorders or congenital malformations. Congenital disorders are the major cause of new born deaths within the perinatal peroid, which can result in long-term disability with a significant impact on individuals, families, societies and health-care systems [ 2 ].  Prenatal diagnosis of congenital disease provides information for decisions during pregnancy and appropriate treatment parentally (timed delivery in tertiary care centers), it is assumed to improve perinatal and longterm outcome. However...

Diseases caused by Pseudomonas syringae and other species of Pseudomonas cause severe losses in different fruit crops worldwide. Antimicrobial peptides (AMPs) are small and consist of a variety of proteins that act on the lipid bilayer of the bacterial membrane that is produced by multicellular organisms. The product, 3 Tac-I/Beta, is a biopesticide that bases its action on three Trichoderma strains ( T. viride strain T-26, T. harzianum strain T-22, and T. longibrachiatum strain T-397), its total concentration is >25 x 10 3 c.f.u. g -1 , which is authorized in Chile to control different fungal diseases in fruit and vegetable crops. However, the reduction of bacterial stone canker disease has suggested a possible AMPs mode of action associated with 3 Tac-I/Beta. In this study we used Transmission Electronic Microscopy (TEM) to assess the possible AMP activity of this product on the bacterial membrane of Pseudomonas syringae pv. syringae (Pss). The effect of two f...

  In some non-voluntary crime is crucial verify the amygdala and limbic system physio-pathology of human responsible of the facts under a Jurisdictional contest. But is relevant to verify this condition in really objective and instrumental way. Many other human physio-pathological conditions are deeply investigated using biochemical or imaging technique: today many organ and system are currently evaluated with high number of biomedical, instrumental or imaging test also In basal or stressing condition. The objective setting of amygdala and limbic system must be added in jurisdictional procedure not as a prove but an additional information to be correctly evaluated. In this work after a literature evaluation some global conclusion are produced. Often is possible to say: One second after often is too much. In many crime situation mindset kinetics of amygdala, limbic system, thalamus is a crucial aspect to be adequately considered in jurisdictional settings. This ne...

Proton-pump inhibitor (PPIs) drugs are widely used in the treatment of gastric diseases. Almost all PPI drugs have some side effects depend on the physical condition and limit of doses. In this study, the physicochemical and pharmacokinetic studies of Omeprazole, Esomeprazole, Lansoprazole and Pantoprazole have been investigated. Density functional theory (DFT) with B3LYP/3-21g basis set has been employed to optimize the geometry and to elucidate their thermochemical, molecular orbital, molecular electrostatic potential properties. Pharmacokinetic parameters are also investigated to compare their absorption, distribution, excretion, metabolism, and toxicity. Omeprazole, lansoprazole, pantoprazole and esomeprazole having the benzimidazole nucleus and widely used in gastrointestinal treatment [1]. They play a significant role as proton pump inhibitors (PPIs) [2].  PPIs are not only very effective but also safer age...

HG Wells has long described the future of mankind in The Time Machine. It is divided into two parts. All the elite - Eloi, will sing and have fun, enjoying the outdoors, eating exclusively vegetable food and fruit. We believe that these are all descendants of the oligarchs, the bureaucracy and the rest of the non-working population. They do nothing, they sleep in big houses without locks. The second part - merlocks - will live underground, produce clothing and footwear for eloi. The vision of the merlock is adapted to the dark. At night, they enter the houses and select the next suitable adult individuals, drag them to their dungeon and eat them. The climate is preserved because there is no arable land, no reservoirs, no landfills. There are no power plants, factories, roads, cities, cars, asphalt. Climate depends on fumes. It is believed that the evaporation of the oceans exceeds the evaporation from land because 3 times the area of the oceans exceeds the area of inhabited land. M...

Physical culture performs in a society a number of general and special functions that are implemented in the form of specialized activities of people associated with the use of physical exercises. Such activity is conditioned by the necessity of using physical exercises in the process of individual development of a person (physical education) [ 1 , 2 ], in the process of carrying out physically active leisure activities (physical recreation, fitness) [ 3 ], in the process of self-expression through adventure activity (sport) [ 4 , 5 ], as well as in other related forms of social practice. In addition to the above-mentioned special functions, physical culture as a special kind of universal culture, performs in society and an integral (human-generating) function, that is, a function that is inherent in all forms of social manifestation of physical culture which determines its integrity. The realization of this function in a social environment has its own peculiarities. Its analysis i...

When I received the report from the doctor with this photo, I was shocked. We seldom see cancer. It is inside. Here a breast tumour has spread to the skin. This is stage 4 cancer, the stage at which most oncologists have ceased trying to stop the cancer. The lady had lost faith in the usual chemo-radiation methods. They didn’t work and had cost her a fortune. Word of mouth led her to a Cell Sonic specialist who was not advertising that Cell Sonic can treat cancer, but the specialist had previous experience and knew that only Cell Sonic could help The doctor asked the lady about the pain on a scale of 1 to 10. She replied 14. It was agony. He gave her one treatment and the pain went away. It is not clear how quickly the pain was quashed, whether it was immediate or within hours. It was also reported that the scales of scabs started to dry out. The doctor was both pleased and perplexed. The result was better than he expected, and he asked for my opinion. There are no side effects...

Implant as a contraceptive device was begun for the clinical trial in 1968 in Santiago, Chile. The tube contained polydimethylsiloxane (silastic or silicon) which was filled by chlormadinone acetate as synthetic gestagen or progestin. However, the trial was stopped due to toxicity in animal experiments. Several years later, six rods implant containing megestrol acetate was run for clinical trial in Chile, India, and Brazil; unfortunately, it stopped because of ectopic pregnancy as consequence of failure. In 1980, there was a trial to compare six- (Norplant®) and two-rod-implant (Norplant-2®) containing levonogestrel (LNG) and continued by the development of Jadena® marketed in Indonesia which was officially accepted by FDA in 1996. Indonesian implant developed single rod marketed as Indoplant® containing 150 mg LNG and Monoplant® consisting of 160 mg LNG. Monoplant® was estimated for 3 years of effectiveness as contraceptive. Therefore, this article would like to present a novel id...

Several pieces of a significantly important research have now come together to present a very different picture of the outcomes we can expect from the current doctrine on hand hygiene in our healthcare facilities. The new evidence, (one piece of which was produced by the BBC TV series “Twinsitutue”), shows beyond any doubt that alcohol gels have the capacity to not only increase the number of bacteria on skin, but to significantly change the species of bacteria that colonise the skin. Further, the species that is shown to replace the natural skin commensals, is a bacillus, this therefore carries an increase risk due to it’s potential for significantly more harm. When alcohol is applied to the skin on hands or the abdomen, two previous research papers, both demonstrate a significant increase in bacterial numbers over time on the hands, and another paper, showed similar results on the abdominal skin prior to surgery. The conclusions of all three papers, was that based on bacter...

The objective of present work was to study the effects of some drugs misused by Sudanese women as body weight gain treatments on complete blood count concentration (CBC) of female rabbits. Sixteen sexually mature female rabbits were procured from local markets of Elnuhod localality, West Kordofan state. A randomized complete block design with three replicates was used; treatments consisted of two drugs i.e. dexamethasone, cyperoheptadine and their combination administered orally with doses of 0.9 mg/kg of body weight with drugs two times a day for 45 days. Experimental animals were divided into four groups each group with four rabbits. First group as a control, while three groups were injected orally with the above-mentioned treatments, blood parameters were measured every two weeks for 45 days, the variance was analyzed, then means were compared by least significant difference (LSD) test. The results showed that the levels of hemoglobin were ranged between 11.15 g/dl and...

The biocompatibility of a material can be defined in the sense that it produces desired or tolerated reactions in a living organism. The metals, in contact with the biological body, give complex effects, producing a series of biological reactions depending on the concentration, the exposure time, etc. According to the biological interaction mode, the metals are divided into: (i) Metallic elements needed in very small concentrations for the living body called essential elements, including cobalt, manganese, zinc, magnesium, sodium, potassium etc.; (ii) Elements that produce toxic effects for the body if present in higher concentrations, the cytotoxic effect being demonstrated by the cell culture system, such as arsenic, cobalt, nickel etc . and (iii) Metals with allergic potential (nickel, cobalt and chromium) are considered to be highly allergic to the body. The overall strategy for testing biomaterials involves assessing them in two ways: (i) “in vitro” evaluation performed on cel...

This is a review study regarding intervention programs for children with Autism Spectrum Disorder (ASD) from a family concept including both children with autism and their parents, because parents are considered essential parts for the successfulness of any intervention programs. ASD is considered to be a long-term neurodevelopmental disorder that is a long-standing problem in the context of social communication and interaction and the dominance of limited, repetitive patterns of behavior, interests or activities. Intervention programs aim to help ASD patients, especially in the early stages of development. Another objective is to involve the parents of children with ASD in order to improve the effectiveness of the implementation of these interventions. Reviewing the literature has shown that parental involvement reduces stress. To view fulltext of article: https://biomedgrid.com/fulltext/volume1/the-assessment-of-intervention-programs-for-autism-including-children-...

He Jiankui, an associate professor at the Southern University of Science and Technology of China was named one of the top ten technology persons by the British Science Journal “Nature” in its electronic version in 2018, and he was selected because of the genetically edited babies that had received widespread condemnation both in China and around the world. The “Science” magazine even ranked this incident as the first of three scientific breakdowns in 2018. On November 26, 2018, the team of He Jiankui announced that two genetically edited babies conducted by their team were born in China. On November 28, He Jiankui claimed at the 2nd International Summit of Human Genome Editing that two little girls who had been genetically edited, “Lulu and Nana were born healthy.” He admitted that the experimental data was leaked, and the research was not peer-reviewed. His team conducted several human trials. To view  fulltext  of article: https://biomedgrid.com/fulltext/volu...

This study was carried out to evaluate the feeding potentials of Amaranthus hybridus stem and Ficus thoningii foliage as supplements to concentrate diet for weaner rabbits over 10 weeks period. A total of 18 crossbred weaner rabbits with average initial weight of 630±10g were used for feeding trial in a completely randomized design experiment. The animals were divided into three groups of six animals per treatment and each treatment had triplicates of two animals per replicate. Treatment T1 was fed with concentrate only. Treatment T2 was fed with concentrate and A. hybridus stem while treatment T3 was fed with concentrate and F. thoningii foliage. Nutrient digestibility of the animals differed significantly (P<0.05) between the groups.  Feed intake and weight gain were higher in T2 than T1 and T3 although feed conversion was better in T1. It is therefore concluded that Amarantus stem can be used as supplement to concentrate diet for weaner rabbits.In recent...

Human papilloma viruses (HPVs) are a group of double-stranded DNA, that cause different type of lesions, also on oral cavity. Lichen planus (LP) is a chronic inflammatory mucocutaneous disease affecting the oral cavity and skin. Photodynamic therapy (PDT) is a treatment used in all fields of medicine, based on the interaction between a photosensitizer, the appropriate wavelength, and oxygen. The reaction generates ROS in cells that take up the photosensitizer, causing cell death by necrosis or apoptosis. Different parameters are described in the literature for PDT. We would like to report a case of a patient with diagnosis of Oral lichen planus that developed, and HPV lesion treated with a particular type of PDT.  I have not found other cases of Photodynamic Therapy for the treatment of oral HPV lesions, in the scientific literature.Human papilloma viruses (HPVs) are a group of double-stranded DNA [ 1 ]. Human Papillomavirus (HPV) infection is considered the most ...

The present study reviewed the literature regarding the impacts of using metronidazole for treating parasitic infections in improving the periodontal health. The prevalence of chronic periodontitis varies between 15-30% among general population. Two important aspects have been discussed, the involvement of using metronidazole treatment for other diseases such as cardiovascular diseases. The other aspect is the existence of patients with poor oral hygiene and accepted gingival health status. We put the link through the use of metronidazole for other diseases such as parasitic infections, which indirectly improves the periodontal and gingival health.  As a conclusion, from a clinical point of view, patients with poor oral hygiene are expected to develop chronic periodontitis, but due to previous treatments for other diseases including parasitic infections that involve the use of metronidazole, the periodontum health has been improved. Accordingly, it is suggested to t...